ABSTRACT
Objective To study the impact of different general anesthesia on T-lymphocyte subsets in patients underwent laparoscopic colorectal resection. Methods 80 patients with laparoscopic colorectal cancer resection were selected from March 2008 to June 2012. According to the difference of general anesthesia, there were 28 patients (Group A). There were 27 patients (group C) who underwent general anesthesia. Patients of the three groups were examined for the level of T lymphocyte subsets during anesthesia. Results CD3+, CD4+ and CD8+ levels were significantly decreased in all the three groups after general anesthesia, CD4+/CD8+ and NK cells in group B were significantly decreased, and CD4+/CD8+ in group C was significantly decreased. The levels of T1 and T2 in group B were significantly lower than those in group A, and the levels of CD3+ and CD8+ in group C were significantly lower than those in group A, and the other indexes except T2 were significantly lower than those of group A, and group C T1 CD8+ was significantly lower than that in group B, NK cells were significantly higher than those in group B, and CD4+in T2 was significantly higher than that in group B. Conclusion Intravenous general anesthesia has the least effect on T lymphocyte subsets in patients undergoing laparoscopic colorectal cancer resection, and the effect on immune function is the slightest.
ABSTRACT
Objective To study the impact of different general anesthesia on T-lymphocyte subsets in patients underwent laparoscopic colorectal resection. Methods 80 patients with laparoscopic colorectal cancer resection were selected from March 2008 to June 2012. According to the difference of general anesthesia, there were 28 patients (Group A). There were 27 patients (group C) who underwent general anesthesia. Patients of the three groups were examined for the level of T lymphocyte subsets during anesthesia. Results CD3+, CD4+ and CD8+ levels were significantly decreased in all the three groups after general anesthesia, CD4+/CD8+ and NK cells in group B were significantly decreased, and CD4+/CD8+ in group C was significantly decreased. The levels of T1 and T2 in group B were significantly lower than those in group A, and the levels of CD3+ and CD8+ in group C were significantly lower than those in group A, and the other indexes except T2 were significantly lower than those of group A, and group C T1 CD8+ was significantly lower than that in group B, NK cells were significantly higher than those in group B, and CD4+in T2 was significantly higher than that in group B. Conclusion Intravenous general anesthesia has the least effect on T lymphocyte subsets in patients undergoing laparoscopic colorectal cancer resection, and the effect on immune function is the slightest.