ABSTRACT
Objective To investigate the expression changes of victims suffering from sudden cardiac death(SCD), eurological calcium adhesion proteins (N-Cadherin) and Bax and explore their significance in forensic medicine. Methods Separately select 33 samples of myocardial tissue suffering from sudden cardiac death and 29 samples of myocardial tissue from the cases which were diagnosed not dying of heart disease as SCD and controls. Histological methods were used to examine the morphologic changes in myocardial tissue, examining the expression changes of N-Cadherin and Bax and analyzing them in a statistic way. Results N-Cadherin was weakly positively expressed in myocardial tissue of group SCD and the cells shew disordered arrangement, which is obviously lower than the controls. The cells exhibited obvious features ordered arrangement in control group. The positive expression of Bax was detected in myocardial tissue of group SCD, which is obviously higher than the controls. Conclusion The expression changes observation of N-Cadherin and Bax will make a difference to the sudden cardiac death.
ABSTRACT
Objective To find out the relationship between kidney- yang- deficiency syndrome and the Th1/Th2 expression, and to investigate the effect of kidney- yang warming therap yon the Th1/Th2 expression. Methods Kidney- yang- deficiency rat models were firstly induced by adenine and then were sensitizated by inhalation of ovalbumin to establish allergic rhinitis (AR)models .The treatment group was given Jinkui Shenqi pill. After treatment , the changes of behavior , secretion of nasal cavity and nasal mucosa were observed. The levels of Th1 cytokines IFN- ? , IL- 2 and Th2 cytokines IL- 4 , IL- 5 in serum were determined by ELISA. Results The behavioral score in AR group and kidney- yang- deficiency AR group was higher than that in the treatment group and normal control group ( P
ABSTRACT
Objective To explore the effect of aluminum on learning and memory and the activity of superoxide dismutase (SOD) in cerebral tissues. Methods 20 mice weighed 18-21g were randomly divided into two groups, the experimental group treated with AlCl3 at 4 mg daily by gavage for 7 weeks and the control group treated with saline. After the treatment, the ability of learning and memory were evaluated by Y-maze test and step-down test, and the activity of superoxide dismutase (SOD) in cerebral tissues was determined. Results In the Y-maze test, the time of up to par in the experimental group (130?13) was significantly more than that in the control(79?7), in the step-down test, the 5 minutes error time in the experimental group(2.5?0.50) was significantly more than that in the control(1.4?0.49), 24 hours retest, the 5 minutes error time in the experimental group(1.3?0.48) was still more than that in the control(0.4?0.29). The activity of SOD in the experimental group[(2.1?0.38)U/mg Pro]showed a significant decrease compared with the control[(3.1?0.21)U/mg Pro]. Conclusion Aluminum can damage learning and memory of mice and can decrease the activity of SOD in the cerebral tissues.