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Based on the teaching practice of literature retrieval of pharmaceutical subject in our school,the paper introduces the rationality of content design,using problem-based learning teaching mode,the connection of practice contents and special subject learning contents,improving the examine mode,offering computer operation and practice,in order to improve the students' comprehensive ability to do scientific research.
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OBJECTIVE: To study the antiemetic effects of Capsicum frutescens and its mechanism.METHODS: Novel vomiting model of minks were established.Inhibition effect of C.fruescens(capsicin as main component) on vomiting behavior induced by cisplatin and apomorphine were observed.The mechanism was investigated through the immunohistochemistry test and the specific 5-HT3-receptor agonist 1-phenylbiguanide hydrochloride(PBG).RESULTS: C.frutescens inhibited vomiting behavior of minks induced by cisplatin and apomorphine(P
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Objective To study the effect of indole- 2,3-dione on the content and release of monoamine neurotransmitters in rat brain.Methods The Wistar rats were given indole-2,3-dione (50,200mg?kg~(-1),ip), and the content of acetylcholine(Ach) and dopamine(DA) in corpus striatum were detected two hours later;the releases of DA,5-hydroxy-tryptamine(5-HT) and norepinephrine(NE) in cortex and corpus striatum slices were examined before and after perfusion with the artificial cerebrospinal fluid(ACSF)that contained indole-2,3-dione. Results The rats given indole-2,3-dione were observed higher concentration of Ach and DA in their corpus striatum compared with that in cortex. Moreover the results also showed indole- 2,3-dione promoted the release of DA in cortex and corpus striatum slices. Conclusion Indole-2,3-dione can regulate the balance between Ach and DA release in rat brain.
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OBJECTIVE:To study the possible mechanisms of the effects of indol-2,3-dione (MW147) on experimental atherosclerosis (AS). METHODS: A total of 120 male quails were randomly divided into six groups: normal control group, model group, lovastatin (79.5 mg?kg-1) positive control group, and MW147 (20, 60, 120 mg?kg-1) groups. The normal control group was fed on normal diet, while the other 5 groups were fed on high lipid diet and treated ig with corresponding drugs for eight weeks. Then the lipid levels including TC, TG, L-DLC and H-DLC in serum and tissues, and the total superoxidedismutase (T-SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and malondialdehyde (MDA) were determined. Meanwhile the tissues of aorta and liver were observed under light microscope. RESULTS: In MW147-treated groups compared with model group, the levels of TC, TG, LDL-C and MDA were decreased while the levels of HDL-C, T-SOD, GSH-Px and T-AOC in serum were increased (P