ABSTRACT
Resumo Fundamento O significado prognóstico dos indicadores nutricionais em pacientes com insuficiência cardíaca com fração de ejeção preservada (ICFEP) não é claro. Objetivo Esta revisão sistemática e metanálise teve como objetivo avaliar o valor prognóstico da albumina sérica (AS), o índice de risco nutricional geriátrico (IRNG) e o índice nutricional prognóstico (INP) em pacientes com ICFEP. Método Os bancos de dados PubMed, Embase, The Cochrane Library e Web of Science foram sistematicamente pesquisados para todos os estudos publicados até janeiro de 2022. O significado prognóstico de IRNG, GNRI e INP para ICFEP foi explorado. A taxa de risco agrupada (HR) e o intervalo de confiança (IC) de 95% foram estimados usando o software STATA 15.0. A Ferramenta de Estudos de Qualidade de Prognóstico foi usada para avaliar a qualidade dos estudos. Resultados Nove estudos preencheram os critérios de inclusão e 5.603 adultos com ICFEP foram incluídos na metanálise. As análises mostraram que uma diminuição de AS ou IRNG estava significativamente relacionada à alta mortalidade por todas as causas (HR: 1,98; 95% IC: 1,282-3,057; p = 0,002; e HR: 1,812;95% IC: 1,064-3,086; p = 0,029, respectivamente). Além disso, uma AS mais baixa indica um resultado composto ruim de mortalidade por todas as causas e reinternação por IC (HR: 1,768; IC 95%: 1,483-2,108; p = 0,000), e um IRNG mais baixo foi significativamente associado a alta mortalidade cardiovascular (HR: 1,922; 95% IC: 1,504-2,457; p = 0,000). No entanto, um INP mais baixo não se correlacionou com mortalidade por todas as causas (HR: 1,176; IC 95%: 0,858-1,612, p=0,314). Conclusões Nossa metanálise indica que AS e IRNG podem ser indicadores úteis para prever o prognóstico de pacientes com ICFEP.
Abstract Background The prognostic significance of nutrition indicators in patients with heart failure with preserved ejection fraction (HFpEF) is unclear. Objectives This systematic review and meta-analysis aimed to assess the prognostic value of serum albumin (SA), the geriatric nutritional risk index (GNRI), and the prognostic nutritional index (PNI) in patients with HFpEF. Methods Databases of PubMed, Embase, The Cochrane Library, and Web of Science were systematically searched for all studies published up to January 2022. The prognostic significance of SA, GNRI, and PNI for HFpEF was explored. Pooled hazard ratio (HR) and 95% confidence interval (CI) were estimated using the STATA 15.0 software. The Quality of Prognosis Studies tool was used to assess the quality of studies. Results Nine studies met the inclusion criteria, and 5603 adults with HFpEF were included in the meta-analysis. The analyses showed that a decreased SA or GNRI was significantly related to high all-cause mortality (HR: 1.98; 95% CI: 1.282-3.057; p = 0.002; and HR: 1.812;95% CI: 1.064-3.086; p = 0.029, respectively). Furthermore, a lower SA indicates a bad composite outcome of all-cause mortality and HF rehospitalization (HR: 1.768; 95% CI: 1.483-2.108; p = 0.000), and a lower GNRI was significantly associated with high cardiovascular mortality (HR: 1.922; 95% CI: 1.504-2.457;p = 0.000). However, a lower PNI did not correlate with all-cause mortality (HR: 1.176; 95% CI: 0.858-1.612, p=0.314). Conclusions Our meta-analysis indicates that SA and GNRI may be useful indicators to predict the prognosis of patients with HFpEF.
ABSTRACT
The objective of this study was to construct three-dimensional (3D) images of premolars to measure the length, surface area and volume of crown and root and to analyze the mathematical relation among crown-to-root ratios in terms of length, surface area and volume. Twenty-five premolars were scanned using micro-computed tomography (micro CT) in vitro to build 3D models. The long axis and enamelo-cemental junction of each tooth were determined with the help of Geomagic Studio software, and the length, surface and volume of crown and root were measured. The crown-to-root ratios in terms of length, surface and volume were calculated and the relationship among length, surface area and volume of crown and root as well their ratios were analyzed using SPSS software. The interrelationship among crown length (x), surface area (y) and volume (z) could be expressed as z= -808.2 0+ 124.80x +3.35y -5.59x2-0.14xy+3.47y 2*10-4 (R2 = 0.99) and that of root length (x1), surface area (y1) and volume (z1), as z1= -207.50 +13.87x1+1.75y1 + 5.03x12*10-2-8.05x 1y1 *10-2+ 2.58*10-3y12 (R2 = 0.93) . The correlation among crown-to-root ratio in length(x2), crown-to-root ratio in surface area (y2) and crown-to-root ratio in volume (z2) could be expressed in z2= -4.48*10-2 -1.25x2*10-2+1.20y2 + 3.29x22-5.05x2y2 + 2.00y22 (R2 = 0.96). The length, surface area and volume of crown and root of premolars share a close relationship, while, a definite mathematical relation could be observed amongst their ratios. Crown to root ratio in terms of length, surface and volume, may provide a novel multi-criterion method for evaluating tooth function.
El objetivo de este estudio fue construir imágenes tridimensionales (3D) de los dientes premolares para medir la longitud, superficie y volumen de la corona y raíz, junto con analizar la relación matemática entre las proporciones de la corona a la raíz en términos de longitud, superficie y volumen. Veinticinco premolares fueron escaneados mediante microtomografía computadorizada (microTC) in vitro para construir modelos en 3D. Con el software Geomagic se determinaron el eje y la unión amelo-cementaria de cada diente, y se midieron la longitud, superficie y volumen de la corona y la raíz de los dientes premolares. Con el programa SPSS se calcularon y analizaron las proporciones de la corona a la raíz en términos de longitud, superficie y volumen y la relación entre la longitud, superficie y volumen de la corona y de la raíz. La interrelación entre la longitud de la corona (x), superficie (y) y el volumen (z) puede ser expresado como z= -808,2 0+ 124,80x + 3,35y -5,59x2-0,14xy + 3.47y2*10-4 (R2= 0,99) y la de longitud de la raíz (x1), área de superficie (y1) y el volumen (z1), como z1= -207,50 + 13.87x1 + 1.75y1 + 5.03x12 * 10-2-8.05x1y1 * 10-2 + 2,58 * 10-3y12 (R2= 0,93). La correlación entre la relación de corona a raíz en longitud (x2), la relación corona a raíz en superficie (y2) y la relación corona a raíz en volumen (Z2) podría expresarse en z2 = -4,48 * 10-2 * 10-2 -1.25x2 + 1.20y2 3.29x22-5.05x2y2 + 2.00y22 (R2= 0,96). La longitud, superficie y volumen de la corona y la raíz de los dientes premolares comparten una estrecha relación, mientras que, una relación matemática definida se pudo observar entre sus proporciones. La relación entre la corona y raíz en términos de longitud, superficie y volumen, puede proporcionar un nuevo método multi-criterio para evaluar la función de los dientes.
Subject(s)
Humans , Bicuspid/anatomy & histology , Tooth Crown/anatomy & histology , Tooth Root/anatomy & histology , Imaging, Three-Dimensional , Pilot ProjectsABSTRACT
<p><b>OBJECTIVE</b>To assess the association of RNASET2 gene polymorphisms and haplotypes with Graves disease (GD) in Han Chinese population from coastal regions of Shandong Province.</p><p><b>METHODS</b>A total of 471 GD patients and 472 controls were enrolled. Genotypes of single nucleotide polymorphisms (SNPs) in RNASET2 gene were determined with a Taqman probe on a Fluidigm EPl platform. Haplotypes and their frequencies were analyzed with a SHEsis online software.</p><p><b>RESULTS</b>There was a significant difference in allele frequencies of rs3777722, rs3777723 and rs9355610 between the GD patients and the controls (P=0.018; P=0.028; P=0.021).Allele frequencies of rs3777722 and rs9355610 were significantly lower in GD than in the controls (P=0.018, P=0.021). Haplotypes A-A-C-A and A-A-T-A were significantly more common in the control group compared with the GD group (P=0.046, OR=0.448, 95%CI:0.200-1.006; P=0.049, OR=0.823, 95%CI:0.678-0.999). The frequency of C-G-C-G haplotype was significantly higher in GD patient group than the control group (P=0.018).</p><p><b>CONCLUSION</b>RNASET2 gene polymorphisms and haplotypes are associated with GD in Han population from coastal areas of Shandong Province. rs3777722 and rs9355610 may contribute to the risk for GD.</p>
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Child , Female , Humans , Male , Middle Aged , Young Adult , Asian People , Genetics , Gene Frequency , Genetic Predisposition to Disease , Graves Disease , Genetics , Haplotypes , Polymorphism, Single Nucleotide , Ribonucleases , Genetics , Tumor Suppressor Proteins , GeneticsABSTRACT
Objective To study the effects of umbilical cord-derived mesenchymal stem cells (MSCs) on the growth and metastasis of lung cancer using Lewis lung carcinoma animal models. Methods Animal models of Lewis lung carcinoma were established in 16 C57BL/6 mice and were randomly divided into normal saline (NS) group and MSC group (n = 8). Mice in the MSC group were injected with 1×106 MSCs via the tail vein at day 7, 12, and 17. All mice were sacrificed to observe the lung metastases and the tumor size at day 21. Results The average tumor weight was (4. 587 5 ± 1. 04) g in the NS group and (4. 155 ± 1. 13) g in the MSC group (P = 0. 59). The average number of lung metastasis nodules was 3. 75 ± 1. 39 in the NS group and 1. 13 ± 1. 13 in the MSC group (P<0. 01), showing an inhibitory rate of 70%. Conclusion Umbili cal cord-derived MSCs have no effects on the growth of Lewis lung carcinoma in mice, but they can inhibit tumor metastasis.