ABSTRACT
Objective To study the association of tryptophan hydroxylase-2 (TPH2) gene polymorphism and antisocial personality disorder (ASPD) and its impulsivity in Chinese Han population. Methods The single nucleotide polymorphism (SNPs) of TPH2 in transcriptional control region,-703G/T,was analyzed by PCR-RFLP genotyping assay in 117 ASPD patients and 142 healthy controls. Barratt Impulsiveness Scale-11 (BIS-11) was used to evaluate the impulsivity of subjects. Results There were significant differences between ASPD and controis on genotype and allele frequencies of TPH2-703G/T (x2 = 7.73, P ＜ 0.05; x2 = 5.12, P ＜ 0.05). The GG genotype and G allele were positively associated with ASPD(OR = 1.458,95% CI = 1.080 ～ 1.968 ;OR = 1.479,95% CI = 1.045 ～ 2.094). The scores of BIS-11 and its factors in GG genotype group((71.28 ± 7.50), (19.60 ±3.41), (25.73 ± 4.92), (25.95 ± 4.77) ) were higher than GT genotype group (( 66.23 ± 8.06), (17.79 ±3.02) ,(23.06 ±3.84) ,(25.38 ±4.97)) and TT genotype group((66.55 ±8.49),(18.50 ±3.35),(23.45 ±4.08), (24.97 ± 4.90)), but only the difference of BIS-11 total scores, the attention and motor factor scores among three groups were statistically significant (P＜0.05). The scores of BIS-11 and its factors in G allele group ((69.38 ±8.04), (18.92 ± 3.36), (24.73 ±4. 69), (25.73 ±4.82)) were higher than T genotype group ((66.41 ±8.22),(17.98 ±3.26),(23.27 ±3.94), (25.15 ±4.89)),however,only the difference of BIS-11 total scores, the attention and motor factor scores between two groups were statistically significant.Conclusion TPH2-703G/T polymorphism may be association with ASPD in Chinese Han population. The GG genotype and G allele may be the risk factors of ASPD and impulsivity.
ABSTRACT
Objective To observe the effects of anti depression therapy on post stroke and neurological rehabilitation in the elderly. Methods There were 178 post stroke depression (PSD) cases. They were divided into 3 groups: 64 cases taking Prozac once every morning about 20 80 mg daily; 58 cases taking amitriptyline twice everyday about 50 100 mg daily and 56 cases taking placebo as control group. All of them were on the regular treatment of cerebrovascular disease. All the cases were evaluated according to the HAMD score, neurological function impairment and ADL before treatment and 1 st , 2 nd , 4 th , 8 th week and 3 rd , 6 th , 12 th month after the treatment. Results At the 2 nd week, HAMD score dropped obviously from 27 7?6 9 to 17 3?5 9 in Prozac group, from 26 9? 6 9 to 15 7?4 2 in amitriptyline group, with significant difference vs pre treatment and the control groups ( P