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Objective To explore the technology frontiers for neuroblastoma treatment from the perspective of patent citation network. Methods Through patent analysis for neuroblastoma treatment, highly cited patents and highly cited papers in the citation network were taken as the research objects. The title and abstract of the citing patents were analyzed by text clustering to identify the technology frontiers. Through social network analysis, the core patents were identified from the indices of degree centrality, betweenness centrality, closeness centrality, and eigenvector centrality. Results A total of 6240 patent applications for neuroblastoma treatment were found, including 71304 patent citations and 88698 journal-article citations. Four technology frontiers were identified based on patent citation network, namely, drug target, drug design, tumor-indication expansion, and gene-expression regulation. Three technology frontiers were identified based on journal-article citation network. They were drug target, drug design, and tumor-indication expansion. Conclusion The development of technology for neuroblastoma treatment continues to be active. Drug target and drug design are the most important technology frontiers. This study could provide certain reference for neuroblastoma treatment from the perspective of information science.
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Objective:By building a COVID-19 related scientific research progress monitoring system, to mitigate the information needs of different stakeholders such as government decision-makers, enterprises and scientific research institutions, provide reference for global scientific research progress monitoring for possible public health emergencies in the future.Methods:Literature review and expert consultation were adopted to systematically sort out the data sources of journal papers, preprints and other scientific papers, formed their respective monitoring catalogs and determined the tracking path.Results:COVID-19-related papers mainly include journal papers and preprints. The data source monitoring range of journal papers includes the official websites of top journals in biomedical and natural sciences, the database Web of Science and Science Direct, and the monitoring scope of the preprint platform includes medRxiv, bioRxiv, and SSRN, etc. In addition, the virological websites virological and nextstrain should also be monitored.Conclusions:COVID-19-related scientific research progress monitoring system can be used for daily monitoring to provide support for decision-making and deployment of prevention and control work.
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This research analyzed Chinese emergency approval policies and practices of medical devices at the local level under the circumstance of COVID-19 disease. The legal basis and administrative system were clarified, the implementation and characteristics of emergency approval policies were investigated, the products information including total approved number, product type and license's validity period were counted. Advices as enhancing the standardization of emergency approval system, strengthening registration guidance and optimize information disclose and management were provided.
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Humans , COVID-19 , Device Approval , Policy , SARS-CoV-2ABSTRACT
Atrial fibrillation is the most common persistent arrhythmia in the clinic. It affects a wide range of populations with high incidence, morbidity and mortality. Clinical studies have shown that ablation is one of the best means for the treatment of atrial fibrillation. However, after receiving ablation, some patients may experience atrial tachycardia and thus feel even deteriorated feelings. Understanding the predicting factors, electrophysiological mechanisms, and differential diagnosis and treatment strategies for post-ablation atrial tachycardia is essential for reducing the incidence and for the management of post-ablation atrial tachycardia. Therefore, we summarize the research progress of the above-mentioned aspects, and correspondingly proposes further research directions.
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Humans , Atrial Fibrillation , Catheter Ablation , Tachycardia, Supraventricular/surgery , Treatment OutcomeABSTRACT
OBJECTIVE@#In this study,computational modelling was used to study whether different conduction pathways have impact on the AF initiation and maintenance based on a human atrial model.@*METHODS@#MRI images from one patient who has atrial fibrillation were used to reconstruct the human atrial anatomical model.The number of MRI images was 112.In order to study the effect of different conduction pathways to AF,4 different atrial models were generated in this study,which were biatrial conduction via only LFO;biatrial conduction via only CS;biatrial conduction via both LFO and CS;model without biatrial conduction.@*RESULTS@#In the case of biatrial conduction simulation via only LFO,the same re-entries were induced as in the LFO and CS case.But for the two cases of only CS conduction and both LFO and CS cannot conduct electricity,one stimulus site induced unsustained re-entry which only lasted for 2 cycles,and then terminated.The other two sites induced the same re-entries as in the previously described two cases,which were biatrial conduction simulation via both LFO and CS and only LFO.@*CONCLUSIONS@#Our simulation showed that these conduction pathways played a minor role in the re-entry initiation and maintenance,the possible explanation is that all the re-entries induced in our simulation is local drivers and maintained by fibrosis.
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Humans , Atrial Fibrillation , Catheter Ablation , Heart Atria , Heart RateABSTRACT
Objective To review the "Twelfth Five-Year Plan" and provide the outlook of the innovation system of Chinese medical science and technology in "Thirteenth Five-Year Plan".Methods This article mainly investigates the layout and results regarding innovation system of Chinese medical science and technology in "Twelfth Five-Year Plan" and the "Thirteenth Five-Year Plan" respectively.Results The layout of the "Twelfth Five-Year Plan" in medical technology field has provide guarantees for promoting the construction of healthy China.Meanwhile,Chinese innovation abilities in this field has been improved.Additionally,technology and equipment in China have been upgraded.However,there are still some problems,such as the lack of original research innovation capacity and urgency in the task of product quality upgrading etc.Since the "Thirteenth Five-Year Plan" is considered as the decisive stage in the process of building Chinese well-off society,it is necessary to increase the layout and investment in terms of innovation system of Chinese medical science and technology.Conclusions On the basis of "Twelfth Five-Year Plan","Thirteenth Five-Year Plan" will grasp the direction of technological progress of medical industry,and continue to promote innovation as well as provide support for improving the abilities of research and development,which could provide an inexhaustible driving force of medical technique innovation for China.
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Objective This paper mainly introduced the present situation of the local talents at Peking University Health Science Center,and proposed some corresponding suggestions for further development.Methods By using the methods of questionnaire investigation and literature review to acquaint the current situation of the local talents.Results The local talents face greater pressure of living stress,their material well-being needs to be improved,physical and psychological condition is poor,and the relationship with the returned overseas talents needs to be adjusted.Conclusions Several suggestions,such as mainly from the structural reform of local talents incentive mechanisms,the improvement of local talents distribution,the attention of the interests of local talents,the strength of self-construction and the coordinated development with overseas talents to promote the construction of the aspects of local talents.
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Objective The measures and suggestions for the management of returned research talents in our country.Methods Through the study of the development of returned research talents in the last five years,Peking University Health Science Center.Results The country has provided a good working and living environment for the returned research talents,but the domestic treatment still has a gap with foreign countries.The differences between the domestic and foreign may cause psychological gap,not easy to adapt.Returned research talents have their own advantages in scientific research,teaching and other aspects,but the research output is relatively slow.Conclusions In terms of policy,academic environment and working environment should be improved.
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Through the analysis of the current status and problems of innovative medical devices evaluation, tnis paper discussed the strategies of evaluation, and ultimately raises the frame of evaluation, so as to provide reference for scientific evaluation of medical devices in China.
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China , Equipment and Supplies , Reference Standards , Evaluation Studies as TopicABSTRACT
〔Abstract〕 The paper elaborates the definition of Biobank and the significance of constructing Biobank standardized system, through comparison of Biobank development process and experiences between China and abroad, it analyzes the existing problems and reasons of Biobank standardized system construction in China, puts forward corresponding advices.
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Technology readiness level (TRL) refers the general maturity level of a single technology or technical systems (including technology,component or subsystem) during the process of development.Base on the original TRL proposed by NASA,with reference to medical device TRL modified by US Department of Defense and NATO,this study modified TRL definition and description for advanced medical devices with consideration of R&D,review and approval characteristics of advanced medical devices in China.
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We searched and retrieved literature on the topic of medical image processing published on SCI journals in the past 10 years. We then imported the retrieved literature into TDA for data cleanup before data analysis and pro cessing by EXCLE and UCINET to generate tables and figures that could indicate disciplinary correlation and research hotspots from the perspective of bibliometrics. The results indicated that people in Europe and USA were leading researchers on medical image processing with close international cooperation. Many disciplines contributed to the fast development of medical image processing with intense interdisciplinary researches. The papers that we found show recent research hotspots of the algorithm, system, model, image and segmentation in the field of medical image processing. Cluster analysis on key words of high frequency demonstrated complicated clustering relationship.
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Humans , Algorithms , Bibliometrics , Cluster Analysis , Diagnostic Imaging , Image Processing, Computer-Assisted , International CooperationABSTRACT
The paper reviewed the development history, current application and technical features of 3D ultrasound and 3D breast ultrasound. 3D ultrasound is used in breast screening methods. Special 3D breast ultrasound equipment can enhance breast characteristics, corresponding the breast characteristics to carry out technological innovation and improvement, provide more accurate and convenient way to inspect breast.
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Female , Humans , Breast Neoplasms , Diagnostic Imaging , Imaging, Three-Dimensional , Ultrasonography, Mammary , MethodsABSTRACT
The key factor responsible for the slowness of registration of medical devices in China is clinical trial. The clinical trial in European and U.S. is taken as an example to analyze the problems in clinical trials in China. Some suggestions are proposed to solve the problem.