ABSTRACT
The ions transport in human cells plays a key role in maintaining normal physiological functions of cells, and the solute transporter(SLC)is responsible for most of the ions transport in somatic cells.The SLC12 family encodes electrically neutral cation-coupled chloride ion cotransporters, which are essential in maintaining intracellular and extracellular chloride balance and related cellular physiological processes.At present, there are 9 members of SLC12 family, and the expression and distribution of these family members are tissue-specific.They are distributed in renal tissues and mainly expressed in renal tubular epithelial cells, and their distribution and expression are significantly different, so their physiological roles in kidney are also different.This article will briefly review the physiological role of SLC12 family in kidney and related renal tubular diseases.