ABSTRACT
Sophorae Flavescentis Radix, drying root of Sophora flavescens which is a leguminous plant of genus Robinia Linn., is rich in a variety of chemical compositions so as to have extensive biological activities. Sophorae Flavescentis Radix Gelatum (SFRG), a product of Guiyang Xintian Pharmaceutical Co., Ltd., is used to treat gynecological chronic inflammations such as cervical erosion, trichomonas vaginitis, and vaginal fungal infection. Recent reports at home and abroad suggest that in addition to the above indications, SFRG has been clinically used in adjuvant physical therapy of cervical erosion and bacterial vaginitis, senile vaginitis, mixed vaginitis vaginal inflammation, and andrology medication. This review is designed to summary these new applications of SFRG.
ABSTRACT
Depression and insomnia are intimately related. Depressed patients usually manifest sleep discontinuity and early awakening, reduced or no slow wave sleep (SWS) and shortened latency of rapid eye movement (REM) sleep. These sleep abnormalities are very similar to those caused by over activated hypothalamic-pituitary-adrenal (HPA) axis with stress. Therefore, the animal models developed by post-traumatic stress disorder or chronic unpredictable mild stress could be used to evaluate drugs which have effects of both anti-depression and improvement of sleep quality, and to provide a more reliable platform for further studis on the mechanisms of depression and accompanied insomnia. This review mainly focuses on the typical features of sleep disturbance of depression, possible pathophysiological mechanisms, establishment of animal stress models and analysis of their abnormal sleep characteristics.