ABSTRACT
The current status and important advances in multi-disciplinary treatment for advanced gastric cancer,including surgery,chemotherapy and radiotherapy,were reviewed in this article.An operative scheme based on the stage and biologic behavior of the tumor is adopted with the D_2 procedure combined with intraoperative peritoneal hyperthermic chemotherapy(IPHC) for stage Ⅱ and Ⅲ patients.Accurate preoperative staging is of utmost importance in making an appropriate therapeutic strategy.For patients with stage Ⅲ_B and Ⅳ gastric cancer,neo-adjuvant chemotherapy followed by cyto-reductive surgery,is helpful to prolong survival and improve the quality of life.Besides the 5-FU,cisplatin and doxorubicin based regimen,combination regimens employing newer generation cytotoxic agents including oxaliplatin,irinotecan,taxanes provided more promising efficacy.Postoperative chemo-radiotherapy is presently under investigation.
ABSTRACT
The detection of carcinoma cells in peripheral blood by ICC and RT PCR is now being paid more and more attention by the clinicians. It can use to recognize the characteristic of metastases, improve the tumor staging, judge the prognosis, establish the treatment scheme and follow up the effects. The most frequent methods being used now are ICC and RT PCR. The tumor specific markers as the majority sample chosen included, specific protein, antigen and gene ect.