ABSTRACT
Objective To study the effect of transvaginal ultrasound on the size of gestational sac and drug abortion, and to explore the relationship between the effect of drug abortion and the gestational sac size.MethodsIn our hospital in July 2016 were treated 50 cases of drug abortion of pregnant women as the research object in the process in February 2015, a retrospective analysis of 50 cases of pregnant women, patients were divided into gestational sac and greater than 10 and less than 10mm to 25mm 25mm three.Transvaginal ultrasound was performed before taking the medicine.After 7 days, the patients were examined by transvaginal ultrasound.The results showed that 7 patients had abortion failure, and the other 5 patients had incomplete abortion.ResultsTransvaginal ultrasound monitoring results can be obtained, the gestational sac size of less than 10 mm in patients with a total of 13 cases, abortion in patients with failure of the 2 cases, incomplete abortion in 4 cases, complete abortion in 7 cases, abortion failure probability was 15.4%.The gestational sac size ranged from 10mm to 25mm in a patient with a total of 25 cases, with a miscarriage of failure in a total of 2 patients, incomplete abortion in a total of 2 patients, complete abortion in a total of 21 patients, and a miscarriage probability of failure of up to & 8%.The gestational sac size is greater than 25 mm in patients with a total of 12 cases, the abortion of the failure of the patients in the 4 cases, incomplete abortion in the 2 cases, complete abortion in the 6 cases, the probability of abortion failure was 33.3%.Therefore, there was a significant difference between the three groups in the rate of abortion failure (P<0.05).ConclusionThe process of drug abortion in pregnant women, the use of transvaginal ultrasound monitoring, can monitor the situation of pregnant women with gestational sac in a certain extent, and that the effect of drug abortion, is conducive to the treatment and the subsequent operation, thereby reducing the pain of patients, improve the success rate of miscarriage.
ABSTRACT
Objective To investigate the effect of soluble endothclial protein C receptor(sEPCR) on natural killer(NK) cells and Th17 cells of epithelial ovarian cancer(EOC) patients and further to study the mechanism of the occurrence and development of epithelial ovarian cancer.Methods 35 cases with epithelial ovarian cancer were selected as the experimental group,and 35 healthy women were chosen as the control group.Peripheral venous blood sample(8 ml)was extracted from each subject.Plasma,serum and peripheral blood mononuclear cells(PBMCs) were obtained from the blood sample.ELISA was used to detect the level of plasma sEPCR and serum IL-17 and IL-21.Flow cytometry was used to detect proportions of NK cells and Th17 cells in PBMCs.Results Compared to the control group,the level of plasma sEPCR in the experimental group increased significantly(P ＜ 0.05).The level of serum IL-17,IL-21 and proportion of NK and Th17 cells in PBMCs significantly decreased(P ＜ 0.05).Correlation analysis showed that sEPCR was negatively correlated with IL-17,IL-21,Th17 cells and NK cells,and the correlation coefficient r was-0.71,-0.62,-0.68 and-0.79,respectively.Conclusion sEPCR in epithelial ovarian cancer patients possibly promotes the proliferation of tumor cells through inhibition of NK and Th17 cells.