ABSTRACT
Objective To investigate the expression of pseudokinase Tribbles homology 3(TRIB3)and its clinical prognostic value in Siewert type Ⅱ adenocarcinoma of esophagogastric junction(AEG).Methods Western blot and immunohistochemical method were used to detect the expression of TRIB3 in R0 resected Siewert type Ⅱ AEG and its corresponding adjacent tissues,and analyze its rela-tionship with clinical parameters,survival and prognosis.Results Western blot analysis showed that the expression level of TRIB3 in Siewert type Ⅱ AEG tissues was significantly lower than that in the adjacent tissues(P<0.05).The immunohistochemical Results showed that the positive expression rate of TRIB3 in cancer tissues was significantly lower than that in adjacent tissues(P<0.01).The expression of TRIB3 was significantly correlated with the degree of differentiation,clinical TNM stage and lymph node metastasis(P<0.05),but not with age,gender and pathological morphology(P>0.05).Kaplan-Meier survival analysis showed that the long-term survival of patients with positive TRIB3 expression was significantly better than that of patients with negative TRIB3 expression(P<0.01).Univariate(HR =0.290,95%CI:0.110-0.761,P =0.012)and multivariate(HR =0.179,95%CI:0.051-0.630,P = 0.007)COX regression analysis showed that TRIB3 could be used as an independent prognostic factor for patients with Siewert type ⅡAEG(P<0.05).Conclusion TRIB3 may be involved in the occurrence and development of Siewert typeⅡ AEG.It is expected to be-come a new target for early diagnosis and treatment of AEG,and can be used as an important indicator for judging the prognosis of patients.
ABSTRACT
Objective To evaluate the safety and efficacy of retroperitoneal laparoscopic procedure for rad-ical nephrectomy. Methods The clinical data of 140 cases underwent retroperitoneal aparoscopic radical nephrec-tomy from August 2013 to December 2015 were retrospectively analyzed. Among them ,87 cases were controlled by procedure for radical nephrectomy ,53 cases were treated with Non-procedural for radical nephrectomy. The peri-operative information parameters of the two groups were compared and analyzed. Results All of the 140 cases were operated under laparoscopy. There was no significant difference between the two groups in the basic condition and tumor location(P>0.05). Retroperitoneal laparoscopic procedure in the operation time ,intraoperative bleed-ing,peritoneal rupture rate,blood transfusion,complete tumor resection and postoperative drainage were better than non-procedural for radical nephrectomy ,the differences were statistically significant(P<0.01). All patients were followed up for 1 to 3 years without recurrence and metastasis. Conclusion Retroperitoneal laparoscopic pro-cedure for radical nephrectomy is significant ,worthy of clinical application and promotion.
ABSTRACT
Objective To evaluate the safety and efficacy of retroperitoneal laparoscopic procedure for rad-ical nephrectomy. Methods The clinical data of 140 cases underwent retroperitoneal aparoscopic radical nephrec-tomy from August 2013 to December 2015 were retrospectively analyzed. Among them ,87 cases were controlled by procedure for radical nephrectomy ,53 cases were treated with Non-procedural for radical nephrectomy. The peri-operative information parameters of the two groups were compared and analyzed. Results All of the 140 cases were operated under laparoscopy. There was no significant difference between the two groups in the basic condition and tumor location(P>0.05). Retroperitoneal laparoscopic procedure in the operation time ,intraoperative bleed-ing,peritoneal rupture rate,blood transfusion,complete tumor resection and postoperative drainage were better than non-procedural for radical nephrectomy ,the differences were statistically significant(P<0.01). All patients were followed up for 1 to 3 years without recurrence and metastasis. Conclusion Retroperitoneal laparoscopic pro-cedure for radical nephrectomy is significant ,worthy of clinical application and promotion.