ABSTRACT
Background Corneal refractive surgery has significant effects on corneal biomechanical properties.However,there are few study on large scale population with corneal biomechanical properties in the myopic population before corneal refractive surgery.Objective This study was to evaluate the change of corneal biomechanical properties and influence factors in myopic eyes using ocular response analyzer (ORA).Methods A prospective cohort study was carried out in Beijing Tongren Eye Center from April 2010 to January 2011.Corneal hysteresis (CH) and corneal resistance factor (CRF) were detected using ORA in 1 792 eyes of 896 myopic subjects who were going to receive corneal refractive surgery under the informed consent.According to different spherical equivalent (SE) the eyes were grouped into-0.25-＜-3.0 D group,-3.0-＜-6.0 D group,-6.0-＜-9.0 D group,-9.0-＜-12.0 D group,-12.0-＜-15.0 D group and ≥-15.0 D group and according to different central corneal thickness (CCT),the eyes were grouped into ＜500 μm group,500-＜550 μm group,550-＜600 μm group and≥600 μm group.The CH value and CRF value in different SE groups or different CCT groups were compared,and the factors influencing CH and CRF were analyzed by Pearson correlation analysis.Results The mean CH and CRF value were (9.84±1.52)mmHg (1 mmHg =0.133 kPa) and (10.46±1.71) mmHg,respectively in the myopic eyes.The CH values were (10.35±1.53),(10.07±1.55),(9.81±1.46),(9.71±1.59),(9.35±1.55) and (9.23±1.28) mmHg in the-0.25-＜-3.0 D group,-3.0-＜-6.0 D group,-6.0-＜-9.0 D group,-9.0-＜-12.0 D group,-12.0-＜-15.0 D group and ≥-15.0 D group,respectively,showing a significant difference among the groups (F=20.69,P＜0.01),and the CH values in the-6.0-＜-9.0 D group,-9.0-＜-12.0 D group,-12.0-＜-15.0 D group and ≥-15.0 D group were significantly lower than those in the-6.0-＜-9.0 D group,-9.0-＜-12.0 D group (all at P＜0.01).There was no significant difference in the CRF values among different SE groups (F =0.65,P =0.49).CH and CRF values were increasing with the raise of CCT,with evidently differences among the CCT＜500 μm group,500 μm ≤ CCT＜550 μm group,550 μm≤ CCT＜600 μm group and CCT≥ 600 μm group (CH:F=110.99,P＜0.01;CRF:F =84.35,P＜0.01),and the CH and CRF values were significantly higher in the 550 μm ≤ CCT＜600 μm group and CCT ≥600 μm group than those in the CCT＜500 μm group (all at P＜0.01).CH showed a positive correlation with SE (r =0.24,P＜0.01),and no significant correlation between CRF and SE (r =0.03,P =0.20).The CH and CRF showed the positive correlations with the CCT (r=0.42,0.57,both at P＜0.01).In addition,CH and CRF values increased as the increases of SE,corneal curvature (CC) and CCT values,with the regression equation of CH =-7.87+0.08SE+0.16CC+0.02CCT (R2=0.26,P＜0.01) and CRF=-11.42+0.14CC+0.03CCT (R2=0.34,P＜0.01),respectively.The CH and CRF did not change with the age and gender in the subjects.Conclusions Corneal biomechanical properties including CH and CRF were positively correlated with CCT,CC and SE.
ABSTRACT
Objective To study the therapeutic effect and safety of acupuncture a long with the deep respiration on patient of acute traumat ic laryngitis. Methods Totally 240 cases with wind heat syndrome were divided into a treatment group (treated by puncturing acupoint Ka iyin 1 as the main point in combination with deep respiration of the patient) and a control group (treated by gentamy cin sulfate and dexamethasone spray-inhalation). After the treatment for 5 days , both groups were observed on the changes of the symptom scores for congest i on and swelling of vocal cords, sore throat, and hoarseness for evaluating the t herapeutic effect and safety. Results On the 3rd day of treatment, the cured and markedly effective rate of the treatment group was sig nificantly higher than that of the control group (P0.05). There was no untowards finding in l aboratory test. Conclusion Puncturing acupoint Kaiyin 1 as the main point in combination with deep respiration of the patient is a effe ctive and safe treatment for acute traumatic laryngitis.