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Objective To compare and analyze the short-term efficacy of modified intermediate laparoscopic right hemicolectomy (LRHC) and traditional intermediate laparoscopic right hemicolectomy (LRHC) in patients with colon cancer.Methods Eighty-four patients with colon cancer treated by laparoscopic right hemicolectomy (LRHC) from March 2014 to March 2018 in the General Surgery department of Guangzhou Hospital of Traditional Chinese Medicine were randomly divided into two groups.The control group was treated with traditional intermediate approach,while the improved group was treated with improved intermediate approach centering on the anterior pancreatic head region,with 42 cases in each group.The two groups of operations and related complications were statistically analyzed and compared.Results Compared to the control group,the improved group had less estimated mean blood loss ((39.5± 11.6) ml vs.(86.3± 13.7) ml,t =11.124,P＜0.05),shorter operative time((104.5±20.5) min vs.(139.3±25.9) min,t =6.094,P＜0.05) and lower intraoperative vascular damage rate (7.1％ (3/42) vs.23.8％ (10/42),x2=7.406,P＜0.05).There were no significant differences in the number of conversion to laparotomy,number of harvested lymph node,postoperative complications,hospital stay and quality of postoperative specimens between the two groups (P＞ 0.05).Conclusion Modified intermediate approach LRHC for colon cancer patients not only reduces the amount of bleeding and operation time,but also significantly reduces the rate of intraoperative vascular injury.
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Objective To explore the predictive value of spleen?liver volume ratio( SLVR) on the prog?nosis of partial hepatectomy in patients with hepatocellular carcinoma. Methods Clinical data of 86 cases of hepatocellular carcinoma underwent hepatectomy who were treated in the Traditional Chinese Medicine Hospital of Guangzhou from January 2009 to December 2014 were analyzed retrospectively. According to the preoperative spleen?liver volume ratio,these patients were divided into 2 groups:those with SLVR5 cm,the number of tumor>3,por?tal vein or hepatic vein tumor thrombus,preoperative AFP?L3%≥10%,the rate of Invasion of blood vessels and the percentage of positive margins of high SLVR group all significantly lower than that of low SLVR group (25. 0%(11/44) vs. 59. 5%(25/42),22. 7%(10/44) vs. 54. 8%(23/42),9. 1%(4/44) vs. 26. 2%(11/42),38. 6%(17/44) vs. 78. 6%(33/42),18. 2%(8/44) vs. 38. 1%(16/42),2. 3%(1/44) vs. 14. 3%(6/42);χ2=20. 645,16. 180,24. 728,4. 819,18. 402,20. 105;P5 cm,SLVR ≥0. 8,AFP?L3≥10%,and portal vein or hepatic vein tumor thrombus were independent predictors of poor disease?free survival after hepatectomy for hepatocellular carcinoma( Or=6. 141, 3. 753,6. 968,7. 763;P<0. 05). Conclusion Preoperative SLVR ≥0. 8 is an independent adverse predictor of poor disease?free survival,can preliminarily predict the prognosis of patients with hepatocellular carcinoma.
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Objective To investigate the effect of ampelopsin on apoptosis induction and cell growth inhibition in Human Colon cancer SW480 cells in vitro.Methods Treated with ampelopsin at several concentrations, MTT and flow cytometry was used to detect the inhibition rate and apoptotic rate of SW480 cells.Western-blot was used to investigate expression of Bcl-2 family pro-tein.Results Significant difference of cell growth inhibition rate was observed among all groups after treated with ampelopsin ( p0.05).The similar results were observed in the experiment on apoptosis induction.Level of Bcl-xL was significantly up-regulated.Level of Bax, Bid, Caspase-3, p-Ca-pase-9 and Caspase-9 was significantly down-regulated after treatment of ampelopsin.Conclusion Ampelopsin can inhibit cell growth and induce apoptosis of SW480.Bcl-2 family protein might be involved in the progress.