ABSTRACT
Clinical data of 210 patients with early colorectal cancer and precancerous lesion treated by endoscopic submucosal dissection (ESD) in the Digestive Endoscopy Center of the Seventh Medical Center of Chinese PLA General Hospital from January 2015 to March 2018 were collected and analyzed retrospectively. Patients were divided into two groups according to the age: the elderly group (≥65 years old, 100 cases) and the non-elderly group (<65 years old, 110 cases). The en bloc resection rate, complete resection rate,and curative resection rate of the elderly group were 92.0% (92/100), 91.0% (91/100) and 89.0% (89/100), respectively. The above indicators of the non-elderly group were 90.9% (100/110) ( P=0.972), 90.0% (99/110) ( P=0.991) and 88.2% (97/110) ( P=1.000), respectively. The incidence of intraoperative perforation in the elderly group was 4.0% (4/100) and in the non-elderly group was 6.4% (7/110) ( P=0.543). Delayed postoperative bleeding rate was 2.0% (2/100) in the elderly group, and 0 (0/110) in the non-elderly group ( P=0.226). ESD is effective and safe in treating early colorectal cancer and precancerous lesion in elderly patients.
ABSTRACT
Objective To explore the efficacy and feasibility of additional liposome doxorubicin with DVD regimen in the treatment of multiple myeloma (MM). Methods Thirty patients with MM in Chinese PLA General Hospital from January 2012 to January 2015 were selected and divided into treatment group (DVD group,liposomal doxorubicin+vincristine+dexamethasone),control group A(VTD group,bortezomib+thalidomide+dexamethasone) and control group B (VAD group, pirarubicin+vindesine+dexamethasone) with 10 cases in each,including 18 males and 12 females,aged from 36 to 72 years old,and the mean age was 55.8 years. The treatment effect and adverse reactions among the three groups were compared. Survival analysis was evaluated through Kaplan-Meier and Log-rank tests. Results Followed up to January 31st 2016, the therapy related mortality rates in three groups were 10%(1/10), 20%(2/10) and 10%(1/10), the total efficiency rates were 80%(8/10), 100%(10/10) and 60%(6/10), the median survival time was 25.5, 25.2 and 21.6 months, the disease free survival rates were 70%(7/10), 80%(8/10) and 50%(5/10). Survival analysis showed that the difference between DVD and VTD group was not significant (P=0.098) and there were significant differences between DVD and VAD group(P=0.027),VTD and VAD group(P=0.012). The incidence of peripheral neurotoxicity in VTD group(70%,7/10)was higher than that in other two group(χ2=14.7,P=0.007), and there was no significant difference in the other adverse reactions among the three group (all P>0.05). Conclusions In the treatment of MM, the efficacy of liposomal doxorubicin enhanced DVD regimen is similar to the VTD regimen and more effective than the traditional VAD regimen. It is a safe and effective method for MM.
ABSTRACT
Objective To explore the efficacy and feasibility of additional liposome doxorubicin with DVD regimen in the treatment of multiple myeloma (MM). Methods Thirty patients with MM in Chinese PLA General Hospital from January 2012 to January 2015 were selected and divided into treatment group (DVD group,liposomal doxorubicin+vincristine+dexamethasone),control group A(VTD group,bortezomib+thalidomide+dexamethasone) and control group B (VAD group, pirarubicin+vindesine+dexamethasone) with 10 cases in each,including 18 males and 12 females,aged from 36 to 72 years old,and the mean age was 55.8 years. The treatment effect and adverse reactions among the three groups were compared. Survival analysis was evaluated through Kaplan-Meier and Log-rank tests. Results Followed up to January 31st 2016, the therapy related mortality rates in three groups were 10%(1/10), 20%(2/10) and 10%(1/10), the total efficiency rates were 80%(8/10), 100%(10/10) and 60%(6/10), the median survival time was 25.5, 25.2 and 21.6 months, the disease free survival rates were 70%(7/10), 80%(8/10) and 50%(5/10). Survival analysis showed that the difference between DVD and VTD group was not significant (P=0.098) and there were significant differences between DVD and VAD group(P=0.027),VTD and VAD group(P=0.012). The incidence of peripheral neurotoxicity in VTD group(70%,7/10)was higher than that in other two group(χ2=14.7,P=0.007), and there was no significant difference in the other adverse reactions among the three group (all P>0.05). Conclusions In the treatment of MM, the efficacy of liposomal doxorubicin enhanced DVD regimen is similar to the VTD regimen and more effective than the traditional VAD regimen. It is a safe and effective method for MM.
ABSTRACT
Opioid-induced constipation (OIC) is the most common side effect of opioid. OIC influences the quality of life of pa-tients suffering from cancer pain. However, given that the drug is often overlooked and underappreciated, most of the time, the patients would avoid or abandon using opioid and, as a result, they continuously suffer from cancer pain. Therefore, OIC prevention and man-agement must be made before opioid use. The consensus on the diagnosis of OIC has only been reached recently. Thus, a unified defini-tion of OIC must be developed to exchange therapeutic option among departments in hospitals and compare treatment outcome. The di-agnosis of OIC is discussed, and the management of OIC, including medicinal and non-medicinal treatment, is summarized. Mean-while, the initial program for prevention and treatment of OIC is established to make OIC management more convenient for clinical physicians. Much work is still needed to establish a consensus on OIC diagnosis and a suitable program for prevention and treatment of OIC.
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Objective To investigate the relationship between the expression of p53 protein and Ki-67 antigen in order to detect its clinical characters and the significance of them in them occurrence and development of appendiceal mucinous neoplasms.Methods 42 tissues of appendiceal mucinous neoplasms were selected by pathological diagnosis in the department of pathology of the PLA general hospital from May 1993 to October 2007.The 10 samples of control group were obtained from simple appendicitis after surgery.Applied PV6000 immunohistochemical method,the expressions of p53 protein and Ki-67 antigen were detected.Results The expression of p53 protein in appendiceal mucinous neoplasms was higher than that in appendicitis tissue [31.0 ％ (13/42) vs 0 (0/10),x2 =4.127,P =0.042).The positive rate of p53 protein in appendiceal mucinous adenocarcinoma was higher than that in low-grade appendiceal mucinous neoplasm tissue (40.0 ％ vs 8.3 ％,x2 =4.0218,P =0.044).The positive rate of p53 protein in appendiceal mucinous neoplasms tissue with pseudomyxoma peritonei was higher than that in tissue without PMP (45.5 ％ vs 15.0 ％,x2 =4.5464,P =0.033).The expression of Ki-67 antigen in appendiceal mucinous neoplasms was higher than that in appendicitis tissue (45.2 ％ vs 10.0 ％,x2 =4.2374,P =0.039).Considering the different factors (such as gender,age,pathological type and PMP),Ki-67 antigen expressions were still not significantly different (P ＞ 0.05).In appendiceal mucinous neoplasms,the difference of positive rates of Ki-67 between the p53 positive expression group and the p53 negative group was statistically significant (x2 =7.6299,P =0.0057).Conclusion The expression of p53 protein was correlated with the expression of Ki-67 antigen.It's valuable that both p53 protein and Ki-67 antigen are used to evaluate the biological behavior of appendiceal mucinous neoplasms and predict the malignant degree.
ABSTRACT
To detect the expression of p16 protein and Ki-67 antigen in gastric mucosa-associated lymphoid tissue lymphoma(MALTL)and normal gastric mucosa and to investigate the clinical significance of their expression in the occurrence and development of gastric MALTL.Methods 47 samples of gastric MALTL diagnosed pathologically in the department of pathology of the PLA General Hospital from March 1993 to June 2005 were collected.By using immunohistochemial methods,the expression of p16 protein and Ki-67 antigen was detected in 20 samples of normal gastric tissue and the 47 samples of gastric MALTL.Results The positive rate of p16 protein Was 21.3%(10/47)and 90.0% in gastric MALTL and normal gastric tissue respectively.The positive rate of p16 protein in gastric MALTL was lower than that in normal gastric tissue(P<0.05).The expression of p16 was related to the degree of lymph node metastasis.The positive rate of Ki-67 labelling index(LI)in gnstric MALTL was hiigher than that in normal gastric tissue.A negative correlation was found between the expression of p16 protein and Ki-67 LI(P<0.05). Conclusions Detection p16 and Ki-67 may help to predict the possibility of lymph node metastasis and prognosis in gastric MALTL.