ABSTRACT
Objective To analyze the different doses of mifepristone in treatment of menopause induced by perimenopausal uterine leiomyoma , and to explore the clinical application of the effective dose of mifepristone.Methods 141 cases with perimenopausal uterine leiomyoma were divided into group A, group B and group C randomly, 47 cases in each group.Three group of patients were given mifepristone.Group A were treated with dose of 12.5 mg/d, group B was treated with 10.0 mg/d, group C was given with 5.0 mg/d.Three groups of patients continued treatment for three months. Uterine volume and leiomyoma volume were observed after treatment, and recorded status of induced menopausal after six months.Results Three groups with uterine volume and leiomyoma volume post-treatment were significantly less than pre-treatment (P<0.05);induction of menopause success rate of group A was 89.4%, menstruation incidence was 6.4%, vaginal bleeding was 2.1%, which was significantly better than the other two groups ( P<0.05) .Conclusion Different doses of mifepristone orally in treatment of perimenopausal uterine leiomyoma has a significant effect, but with 12.5mg/d induced menopause can effectively enhance the success rate , it could be used as the optimal dose of clinical treatment.
ABSTRACT
Objective To explore the comparison of efficacy of Salmeterol assigned powder inhaler and Aminophylline Tablets treating female COPD with remission.Methods Selected in remission of COPD in female patients of 114 cases.With digital method were divided into observation group and control group with 57 cases in each group.The observation group inhaled salmeterol and fluticasone propionate powder,while the control group oral amin-ophylline tablets for treatment.Effect and Lung function index,such as IC,FEV1 ,FVC,FEV1 % etc.were compared between the two groups after the treatment.Results The observation group treatment effects achieved significantly accounted for 47.37% (27 /57),which was significantly higher than 26.32% (15 /57)in control group,and the total effective rate of the observation group was higher(χ2 =4.150,P =0.042).In addition,the IC,FEV1 ,FVC,FEV1 %index increased significantly in the observation group after treatment,and the TDI,6MWD was also higher.The difference was statistically significant (t =5.077,4.746,P =0.000,0.000).Conclusion Salmeterol and fluticasone propionate inhalation and aminophylline tablets in the treatment of female remission of COPD showed a high efficient results,but the relative effect of salmeterol and fluticasone propionate inhalation therapy effect is better,the degree of dyspnea alleviated better.