Research progress on molecular mechanism of Dendrobium officinale and its active components to metabolic syndrome / 中国中药杂志

Metabolic syndrome,a kind of clinical syndrome marked by the presence of symptoms such as hyperglycemia,dyslipidemia and hypertension,has an increasing incidence and comes to be present in younger people. More importantly,prolonged maintenance of this condition can significantly increase the incidence of chronic diseases such as diabetes,cardiovascular disease and cancer.However,the formation mechanism of metabolic syndrome is very complex and has not been fully studied and revealed. Dendrobium officinale is a traditional medicine and food substance with multiple physiological functions. In recent years,D. officinale has attracted much attention from the scholars both at home and abroad due to its functions such as improving blood lipid,lowering blood pressure and regulating blood sugar. However,there is no systematic review on the current studies about D. officinale in intervening metabolic syndrome and its underlying molecular mechanism. In this paper,the biological activity of the main active components,and the research or application status of D. officinale extract in the recent years were reviewed. Then,we analyzed the digestion,absorption and the safety and toxicity of D. officinale and its active components in the body. Finally,we summarized the effects of D. officinale and its active components on metabolic syndrome in animals and human bodies,and discussed its possible molecular mechanisms at the cellular level. This paper provides solid theoretical guidance and reliable molecular basis for further research and advanced development of D. officinale and its active components,especially for its oncoming clinical application.

Soluble guanylate cyclase stimulators:research advances / 国际药学研究杂志

The soluble guanylate cyclase (s GC) is a key signal transduction enzyme in the nitric oxide (NO) -sGC-cyclic guanosine monophosphate (cGMP) pathway, which can be activated by NO and thus catalyzes the conversion of guanosine triphosphate (GTP) into the c GMP. As a second messenger, cGMP modulates the activity of downstream effectors, including the cGMP-dependent protein kinases (cGK), cGMP-dependent phosphodiesterases (PDE) and ion-gated channels, and ultimately participates in the regulation of several physiological functions, including the function of cardiovascular, gastrointestinal and central nervous systems. sGC stimulators could not only directly stimulate s GC but also synergistically act with NO to increase the sGC enzyme activity, which has shown a great potential to treat various diseases via regulating the NO-s GC-cGMP signaling pathway. Here, we give an overview of NOindependent sGC stimulators in clinical trial.