ABSTRACT
@#Neovascular glaucoma(NVG)is a refractory blinding eye disease that adds a heavy burden to society. The incidence of neovascular glaucoma is related to a variety of factors, such as retinal ischemia and hypoxia, inflammation and trauma. There are more than 40 diseases that can cause it to occur, among which the most common in clinical is diabetic retinopathy and central retinal vein occlusion. Because of its complex etiology and the pathogenesis remains unclear, clinical treatment is extremely difficult. This paper summarizes some related researches in recent years. Finally, the onset and treatment of neovascular glaucoma are elaborated in order to be expected to help clinical work.
ABSTRACT
Aim To investigate the alteration of volt-age-depending potassium channel(KV) current in pul-monary arterial smooth muscle cells(PASMCs) of pul-monary hypertension (PH) rats, and the effect of tet-raethylammonium (TEA,a blocker of KV) on potassi-um channel current in different PH models. Methods The whole-cell patch clamp techniques were applied to record the KVcurrents from PASMCs cultured with Ham's F-12 (1% FBS). Furthermore, the effects of TEA on the KVcurrents were examined in different PH models. Results The whole-cell KVcurrents were ob-viously inhibited in PASMCs of chronic hypoxia (CH)and monocrotaline (MCT)-treated rats. TEA signifi-cantly decreased the whole-cell KVcurrents in PASMCs of control and PH rats,and the inhibitory effect of TEA was dramatically reduced in PH group. Conclusions The degree of the voltage-dependent potassium chan-nels opening is significantly inhibited in PASMCs of CH and MCT-treated rats,accordingly,the TEA-sen-sitive KVcurrents obviously decrease.