A new guaiane-type sesquiterpenoid from Croton yunnanensis / 中国中药杂志

Five sesquiterpenoids were isolated from 90% ethanol extract of Croton yunnanensis by silica gel,Sephadex LH-20 column chromatography,as well as prep-HPLC methods. Based on MS,1 D and 2 D NMR spectral analyses,the structures of the five compounds were identified as 11-methoxyl alismol(1),6β,7β-epoxy-4α-hydroxyguaian-10-ene(orientalol C,2),multisalactone D(3),arvestonol(4),and 4,5-dihydroblumenol A(5). Compound 1 was a new guaiane-type sesquiterpenoid. Compounds 2-4 were isolated from the Croton genus for the first time,and compound 5 was obtained from this plant for the first time.

Study on Medication Rules of Li Xu Yuan Jian Based on Data Mining / 中国中医药信息杂志

Objective To analyze the medication rules in Li Xu Yuan Jian; To explore the medication characteristics of WANG Qi-shi’s treatment for deficiency syndromes and hisdialectical thinking; To provide references for clinic. Methods By combing the recorded prescriptions in Li Xu Yuan Jian , this article established the database of medicine names, dosage and syndromes. SPSS statistical software 19.0 was used for universal analysis, similarity analysis, and cluster analysis. Results 23 prescriptions were included in the study, involving 56 kinds of medicine and 227 frequency, among which the most commonly used medicine were Glycyrrhizae Radix et Rhizoma and raw Rehmanniae Radix; The medicinal properties were mainly cold (46.7%), warm (16.7%), and flat (16.7%), and the medicinal tastes were mainly bitter (53.3%), sweet (80.0%), and octanol (20.0%), and the meridians were mainly Heart Meridian of Hand-Shaoyin (53.3%), Liver Meridian of Foot-Jueyin (33.3%), Spleen Maridian of Foot-Taiyin (53.3%), Liver Meridian of Hand-Taiyin (66.7%), Kidney Meridian of Foot-Shaoyin (46.7%), and Stomach Meridian of Foot-Yangming (26.7%). Conclusion In Li Xu Yuan Jian, WANG Qi-shi tends to treat deficiency syndromes by using medicine with the cold property, sweet taste and Liver Meridian of Hand-Taiyin, among which Glycyrrhizae Radix et Rhizoma and raw Rehmanniae Radix were most commonly used, followed by Platycodonis Radix, Poria, Ophiopogonis Radix and Moutan Cortex to protect the lung. Therefore, the final and upmost goal of not hurting qi and tonifying lung and kidney can be achieved.