ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship among the serum D- two polymer, fibrinogen, C reactive protein and interleukin 6 and thrombus dissolution volume in acute iliac femoral venous thrombosis model rats.</p><p><b>METHODS</b>A total of 60 rats were randomly divided into 3 groups: deep venous thrombosis group (DVT group), sham operation group and normal control group. In DVT group the single side of the iliofemoral vein incomplete with micro vessel was cliped under chloral hydrate anesthesia; in sham operation group the single side of the iliofemoral vein should be explored without using micro vessel clip under chloral hydrate anesthesia; the and normal control group only experienced chloral hydrate anesthesia. A positive correlation was showed between the 2 time points of D-dimer and the corresponding thrombolytic volume, and the Pearson coefficient was 0.307, and Rwas 0.412 (P<0.05).</p><p><b>RESULTS</b>The D-dimer, fibrinogen, C reactive protein and interleukin-6 levels before and after treatment of 60 rats were shown to be significantly different (P<0.05) between DVT group, sham operation group and normal control group. The D-dimer and fibrinogen level was first rised and then decreased in DVT group, sham operation group. There was a positive correlation between C reactive protein/interleukin-6 and the level of D-dimer /fibrinogen from T1 to T3 time point (P<0.05). There was a negative correlation between C reactive protein/interleukin-6 and the level of D-dimer /fibrinogen from T4 to T6 time point (P<0.05).</p><p><b>CONCLUSION</b>The changes of serum D-dimer, fibrinogen, C reactive protein and interleukin 6 in the acute iliac femoral vein thrombosis model firstly increase and then decrease. These changes can reflect the process of blood coagulation and fibrin dissolution in the course of venous thrombosis of iliac vein.</p>
ABSTRACT
Objective ] To investigate the disease burden level and trend of leukemia in Ningbo City of Zhejiang Province. [ Methods ] Disability adjusted life years ( DALY ) of leukemia was calculated for residents on the basis of leukemia monitoring data in Ningbo City. [ Results] The disease burden of leukemia in Ningbo City was 30 681.26 DALYs; the intensity was 1.06 DALYs per 1 000 population.The disease burden and intensity of leukemia in male was higher than that in female.The disease burden of leukemia was focused on those aged 40 years and above.The disease burden intensity was rising year by year. [ Conclusion] The disease burden of leukemia in Ningbo City has been relatively stable.It is suggested that the health administrative departments should enhance prevention and control of leukemia in those under 10 years and those aged 50 and over, so as to reduce the disease burden resulting from leukemia.