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1.
China Journal of Chinese Materia Medica ; (24): 3176-3178, 2012.
Article in Chinese | WPRIM | ID: wpr-308624

ABSTRACT

<p><b>OBJECTIVE</b>To study the total content change of psoralea and isopsoralea in Psoralea corylifolia under different temperature, and predict its term of validity by initial average rate stability test in order to provide the basis for assessing its quality.</p><p><b>METHOD</b>The reaction rate constant K was replaced by initial velocity V. According to Arrhenius rule, storage period was obtained at room temperature.</p><p><b>RESULT</b>The stable life of P. corylifolia has been determined as 0.53 years.</p><p><b>CONCLUSION</b>The high temperature is not conducive to the stability of the P. corylifolia, which need to store in a dark and cool place.</p>


Subject(s)
Drug Stability , Psoralea , Chemistry , Temperature
2.
China Journal of Chinese Materia Medica ; (24): 3179-3181, 2012.
Article in Chinese | WPRIM | ID: wpr-308623

ABSTRACT

<p><b>OBJECTIVE</b>To study the content change of chlorogenic acid in honeysuckle under different temperature, and predict its term of validity at room temperature.</p><p><b>METHOD</b>The content of chlorogenic acid was assayed by HPLC. The activation energy E(a) and the decomposition rate constant K were calculated by initial average rate stability tests and the prediction was carried out.</p><p><b>RESULT</b>The stable life of honeysuckle has been determined as 1.29 years.</p><p><b>CONCLUSION</b>The initial average rate stability test was used to predict stable life of honeysuckle, and the results are credible. Higher temperature should be avoided for honeysuckle store, and room temperature should guarantee its quality during storage.</p>


Subject(s)
Chlorogenic Acid , Chromatography, High Pressure Liquid , Drug Stability , Lonicera , Chemistry , Temperature
3.
China Journal of Chinese Materia Medica ; (24): 3182-3184, 2012.
Article in Chinese | WPRIM | ID: wpr-308622

ABSTRACT

<p><b>OBJECTIVE</b>To study the stability of chlorogenic acid, cynaroside and 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju and to predict their term of validity.</p><p><b>METHOD</b>Hangbaiju and Gongju were incubated in an environmental chamber at different temperatures and relative humidities. After the incubation, quantitative determination of chlorogenic acid, cynaroside, 3,5-O-discaffeoylquinc acid in Hangbaiju and Gongju were measured by HPLC. The effective period of the preparation was calculated according to Arrhinius index law. Quantitative determination of 3,5-O-discaffeoylquinc acid, cynaroside, chlorogenic acid in Hangju and Gongju were analyzed by HPLC.</p><p><b>RESULT</b>The stable life of Hangbaiju has been determined as 2.25 years. The stable life of Gongju has been determined as 4.31 years.</p><p><b>CONCLUSION</b>The high temperature is not conducive to the stability of Hangbaiju and Gongju, which needs to be placed in a dark and cool place.</p>


Subject(s)
Chlorogenic Acid , Chromatography, High Pressure Liquid , Chrysanthemum , Chemistry , Drug Stability , Drugs, Chinese Herbal , Chemistry , Temperature
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