ABSTRACT
Objective To explore the risk factors of cerebral infarction in youth,and to provide evidence for prevention and control. Methods A total of 105 patients aged 35 -45 years old with cerebral infarction in the affiliated hospital of Shaoxing University from January 2010 to October 2014 were recruited as the cerebral infarction group . The healthy people without neurological symptoms were recruited as the control group. The two groups were compared for the risk factors of cerebral infarction in the youth. Results Logistic regression analysis showed that high blood pressure,diabetes,lipid disorders, smoking,obesity,unstable plaque,high homocysteine and anti - cardiolipin antibodies were the risk factors for cerebral infarction in the youth. The value of ORs and 95% CIs interval value for high blood pressure,diabetes,lipid disorders, smoking,obesity,unstable plaque,high homocysteine and anti - cardiolipin antibodies was 14. 614(0. 469 -47. 273),5. 129 (1. 541 -28. 466),44. 970(2. 789 -101. 549),26. 180(1. 085 - 51. 912),45. 196(2. 572 - 205. 674),258. 786(4. 892 -367. 678),14. 585(1. 770 - 49. 662)and 5. 145(1. 005 - 20. 293),respectively. Conclusion High blood pressure, diabetes,lipid disorders,smoking,obesity,unstable plaque,high homocysteine and anti - cardiolipin antibodies were closely related with cerebral infarction in the youth,and it is necessary to prevent and control the influencing factors and diseases.
ABSTRACT
Objective To explore the relationship between serum anti - cardiolipin antibodies( ACA ) and recurrent cerebral infarction( RCI),and to provide the clinical evidence for the prevention and treatment of RCI. Methods One hundred and ten patients with RCI,120 patients with primary cerebral infarction( PCI)and 150 healthy controls were recruited. Serum ACA was detected using quantitative enzyme linked immunosorbent assay( ELISA)and the positive rate of ACA was compared between these three patient groups. Results The positive rate of serum ACA of RCI group (31. 82%)was higher than that of PCI group( 15. 00%)( P <0. 05 ). Compared with patients above 50 years old (11. 56%),the patients under age of 50 had a higher positive rate of ACA( 57. 89%)( P <0. 05 ). There was no significant difference between males( 22. 52%)and females( 23. 53%) in positive rate of ACA( P > 0. 05 ). The recurrence rate(56. 25%)of ACA positive patients was higher than that of ACA negative patients(29. 79%)after one year follow up(P<0. 05). Conclusion Higher positive rate of serum ACA is observed in RCI patients. The PCI patients with high positive rate of serum ACA has an increased susceptibility for RCI. ACA detection is important for prediction and clinical intervention of the recurrence of cerebral infarction.