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Chinese Journal of Medical Genetics ; (6): 616-618, 2013.
Article in Chinese | WPRIM | ID: wpr-254550

ABSTRACT

<p><b>OBJECTIVE</b>To develop a method for evaluating the feasibility of prenatal screening using local median value and determining the cut-off value.</p><p><b>METHODS</b>With receiver operating characteristic curve (ROC) analysis, results of second trimester prenatal screening calculated by a local median value in a new model and the built-in median value in 2T software were compared. The cut-off value was set by serial analysis of true and false positive rates and other relevant data.</p><p><b>RESULTS</b>The ROC curve has accurately estimated the difference in the screening efficacy between a local median value and that embedded in the 2T model, and established a reasonable cut-off value for the laboratory based on false positive rate and detection rate.</p><p><b>CONCLUSION</b>The method of ROC curve can be used to evaluate the performance of local median value in prenatal screening and to test the rationality of cut-off value established in the laboratory. As the result, a better cut-off value may be derived.</p>


Subject(s)
Female , Humans , Male , Pregnancy , China , Epidemiology , Down Syndrome , Diagnosis , Epidemiology , Genetics , Pregnancy Trimester, Second , Genetics , Prenatal Diagnosis , Methods , Reference Standards , ROC Curve , Software
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