ABSTRACT
Objective To summarize the effect of individualized rehabilitation nursing combined with music therapy on one patient with severe pneumonia complicated with multiple organ failure. Methods Based on the comprehensive evaluation of patients,the rehabilitation programs including critical care,person-alized rehabilitation care and personalized music therapy were established,and the corresponding nursing mea-sures and muscle training were implemented. Results After careful nursing, music therapy and muscle training for seven days, the score of Acute Physiology and Chronic Health Evaluation Scoring System (APACHE II) decreased from 28 to 14; the upper limb muscle strength increased;the score of Self-rating Anxiety Scale(SAS)decreased from 71 to 52;the score of Fugl-Mey-er Assessment(FMA)increased from 38 to 80;and modified Barthel index increased from 0 to 55. Conclusion Personalized rehabilitation care could effectively promote the recovery,and increase the activities of daily living of patients with severe pneumonia complicated with multiple organ failure.
ABSTRACT
OBJECTIVE@#To explore the relation between changes in expression of aquaporin-4(AQP4) protein and acute radiation-induced cerebral edema after Gamma knife radiation.@*METHODS@#The experimental model was established in rats by radiating 2 mm right to median line in cerebral hemisphere with 50 Gy Gamma knife (the center located at the line of auditory canal). The changes of brain water content were measured by the wet and dry weight method. Immunohistochemistry was used to determine the change of expression of AQP4 protein at different periods after Gamma knife radiation.@*RESULTS@#The brain water content and the expression of AQP4 in the target area and the peripheral zone obviously increased at 12 h after Gamma knife radiation, and achieved the peak after 2 d. It was still higher than normal after 14 d. The gray value of expression of aquaporin-4 was negatively related to brain water content (r=-0.9857, P<0.05).@*CONCLUSION@#AQP4 has a close relationship with acute radiation-induced cerebral edema.
Subject(s)
Animals , Female , Male , Rats , Acute Disease , Aquaporin 4 , Brain Edema , Metabolism , Radiation Injuries, Experimental , Metabolism , Radiosurgery , Random Allocation , Rats, Sprague-DawleyABSTRACT
OBJECTIVE@#To evaluate the outcome of gamma knife for prolactinomas.@*METHODS@#Eighty-nine patients were treated by gamma knife and 51 were followed up. The dose to the tumor margin ranged from 18 Gy to 35 Gy (mean 26.1 Gy). The maximum radiation dose varied from 36 Gy to 60 Gy (mean 50.41 Gy). The mean tumor diameter was 15.5 mm (5 - 26 mm).@*RESULTS@#The follow-up data were available for 51 patients ranging from 6 to 108 months (mean 37 months). The tumor growth control rate was 100%. The endocrinological remission rate was 40%. The rate of hypopituitarism was 17.6%.@*CONCLUSION@#Gamma knife radiosurgery can be used as a primary treatment for selected prolactinomas,especially for pituitary microadenomas.