ABSTRACT
Objective To investigate clinical effect of breviscapine combined with nerve growth factor in treatment of ischemic optic neuropathy . Methods 80 patients with ischemic optic neuropathy from March 2014 to March 2016 in our hospital were selected and divided into the control group and observation group, 40 cases in each group.The control group was treated with nerve growth factor, hip injection 30ug, one times a day, while the observation group was treated with breviscapine combined with nerve growth factor, 80 mg breviscapine added to 500 mL glucose intravenous infusion, one times a day.Then the changes of visual acuity, visual field loss difference (LV), the average damage of vision (MD), the average vision light sensitivity ( MS ) , adverse reactions, curative effect were compared between two groups.Results After treatment, the total effective rate in the observation group was significantly higher than the control group, the difference was statistically significant (P<0.05), the visual acuity of the observation group was significantly higher than that of the control group, the difference was statistically significant (P<0.05), LV, MD was significantly lower than the control group, the difference was statistically significant (P<0.05), MS was significantly higher than the control group, the difference was statistically significant (P<0.05).There was no difference in adverse reactions between the two groups.Conclusion Breviscapine combined with nerve growth factor in the treatment of ischemic optic neuropathy can improve nerve function of patients , improve the therapeutic effect.
ABSTRACT
Objective To investigate the effect and clinical efficacy of pranoprofen eye drops on lysozyme, EGF and LF levels in type 2 diabetic patients with dry eye syndrome.Methods70 Type 2 diabetes patients with dry eye from department of ophthalmology, Yuyao People's Hospital of Zhejiang Province from September 2013 to May 2015.They were selected and randomly divided into the treatment group and the control group with 35 cases in each group.The control group were treated by artificial tears eye drops 0.1mL/time, 6 times/day treatment.The treatment group were treated on the base of the control group with pranoprofen eye drops 0.15mL/eye drops, 4 times/day treatment.2 groups were 14 days for 1 courses of treatment, a total of 2 courses of treatment.The tear break-up time, basal lacrimal secretion, corneal fluorescein staining positive rate and clinical efficacy were compared between two groups before and after treatment.ResultsWith the total effective rate in the treatment group,was higher than the control group(P<0.05).Compared with before treatment, the tear break-up time prolonged, basal lacrimal secretion, tear lysozyme, EGF and LF levels were higher(P<0.05), the positive reaction rate of corneal fluorescence staining was lower(P<0.05).Compared with the control group after treatment, the tear break-up time prolonged, basal lacrimal secretion, tear lysozyme, EGF and LF levels were higher(P<0.05), the positive reaction rate of corneal fluorescence staining was lower(P<0.05).ConclusionThe clinical efficacy of pranoprofen eye drops in type 2 diabetic patients with dry eye syndromeis good.It is speculated that the mechanism and tear break-up time prolonged, basal lacrimal secretion increase and lysozyme, epidermal growth factor(EGF)and the level of LF increased.