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Objective To explore the prognostic significance of T wave direction in lead aVR in patients with acute ST-segment elevation myocardial infarction (ASTEMI).Methods A total of 322 patiens with ASTEMI was examined.The patients were classified into 2 groups (T-wave positive,and T-wave non-positive) base on the direction of T wave in lead aVR.This study was ought to determine the association of T wave direction in lead aVR with the incidence rate of major adverse cardiac events (MACE) after discharge 2 years.Results After discharge 2 years,T-wave positivity patients had higher incidence of MACE than T-wave non-positive patients (P ＜ 0.05).Multivariate Cox proportional hazards regression analyses showed that age,and upright T wave in lead aVR were significantly associated with the primary end point.Conclusions T wave direction in lead aVR is a powerful prognostic marker for long-term prognosis.
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Objective To detect the impact of Diltiazem on the major adverse cardiac events (MACE) in six months after percutaneous coronary intervention (PCI).Methods A total of 192 patients after PCI with coronary atherosclerotic heart disease were enrolled in this study.The patients were randomly divided into Diltiazem therapy group (101 patients) and non-Diltiazem therapy group (91 patients).The high-sensitivity C-reactive protein (hs-CRP) was assessed before and 24 h after PCI,and the incidence of Major adverse cardiovascular events(MACEs) were assessed at the sixth month after PCI.Results Compared with before PCI,hs-CRP level increased significantly in both group after PCI (P＜0.01),but hs-CRP level was lower in Diltiazem therapy group than in non-Diltiazem therapy group (P＜0.05).Compared with non-Diltiazem therapy group,there was lower incidence of MACEs during six months follow-up in Diltiazem therapy group.Conclusions Diltiazem can decrease the incidence of MACEs during six months after PCI.
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OBJECTIVE@#To explore the alteration and the clinical significance of QT dispersion in acute pulmonary embolism (PE).@*METHODS@#From May 2011 to April 2012, 42 hospitalized PE patients in Xiangya Hospital of Central South University were enrolled, and divided into a high-risk group and a non-high-risk group according to the clinic state on admission. Another 30 healthy subjects with matched age and genders were enrolled as a normal control group. QT interval was measured manually in 12- lead conventional electrocardiogram within 24 hours on admission and after the treatment. QT dispersion (QTd) and heart rate-corrected QT dispersion (QTcd) were also calculated. All patients were followed up during hospitalization, and were divided to a death group and a survival group.@*RESULTS@#QTd and QTcd in the high-risk group [(70.2±34.0), (88.1±43.3) ms] and the non-high-risk group [(49.3±21.8), (59.1±26.2) ms] were significantly higher than those in the normal control group[(33.2±12.4), (36.7±14.2) ms] (P0.05). Logistic regression showed that high-risk of PE, right ventricular dysfunction and high QTcd after the treatment were the main risk factors of hospital death.@*CONCLUSION@#QTd and QTcd are increased in PE. PE patients with right ventricular dysfunction, high-risk of PE, and high QTcd after the treatment suggest weak prognosis.