ABSTRACT
Objective:To investigate the effects of laparoscopy assisted complete mesocolon resection on the stress response and immune function of patients with colon cancer.Methods:From January 2013 to January 2016,130 patients with colon cancer in our hospital were selected and randomly divided into the observation group and the control group with 65 cases in each group according to the random lottery envelopes.The observation group was treated with laparoscopy assisted complete mesocolon resection,the control group was treated with open operation.The changes of semm IL-6,TNF-α and amours of CD4+ cells,blood loss,bowel function restoration time,hospital stays and complication rate of two groups were compared before and after treatment.Results:Both groups of patients were successfully completed the surgery and there was no serious complications occurred in both groups.The amount of bleeding,postoperative intestinal recovery time and postoperative hospital stay in the observation group were significantly less than those of the control group (P＜0.05).The chylous fistula,wound infection,pulmonary infection and complication rate on the 14th day postoperation in the observation group was 1.5％,which was 12.3％ in the control group and significantly higher than that of the control group (P＜0.05).The contents ofCD4+ cells in the observation group and the control group were 36.34± 7.83％ and 33.66± 9.82％,respectively,which were significantly higher than those before treatment(30.33± 6.49％ and 30.49± 5.33％)(P＜0.05),and the contents of CD4+ cells of observation group was significantly higher than that of the control group after treatment (P＜0.05).The serum levels ofIL-6 and TNF-α in both groups were significantly lower than those before treatment on the 14th day postoperation (P＜0.05),and the serum IL-6 and TNF-α levels of observation group were significantly lower than those in the control group on the 14th day postoperation (P＜0.05).Conclusion:Laparoscopy assisted complete mesocolon resection could promote the immune function and inhibit the stress response,which further promoted the rehabilitation and induced the complications in the treatment of patients with colon cancer.
ABSTRACT
Objective To observe the effect of Pulmicort Respules combined with Tiotropium Bromide in the treatment of chronic obstructive pulmonary disease (COPD) and its influence on inflammatory cytokines.Methods 130 COPD patients which met inclusion criteria were randomly divided into the observation group (65 cases) and control group (65 cases).Both two groups were given conventional therapy,the control group was given a separate aerosol inhalation of Pulmicort Respules,the observation group was inhaled Tiotropium Bromide on the basis of the control group.Both two groups were treated for 14d,the symptoms and signs were observed before and after treatment.The respiratory function and blood gas were monitored,and induced sputum was used to determine inflammatory cytokines levels of airway.Results (1) After treatment,the FEV1,FEV1/predicted,FEVi/FVC,PaO2 of the observation group were significantly increased,the PaCO2 was significantly reduced,but FEV1/FVC of the control group had no significant change after treatment.(2) The lung function and blood gas between the two groups had no statistically significant differences before treatment.After treatment,the FEV1,FEV1/predicted,FEV1/FVC,PaO2 of observation group were obviously higher than those of the control group,PaCO2 was significantly lower than the control group.(3) After treatment,the IL-8,TNF-α,neutrophil cell ratio of two groups were significantly lower than before treatment.(4) The IL-8,TNF-α,neutrophil cell ratio had no statistically significant differences before treatment between two groups.After treatment,the IL-8,TNF-α,neutrophil cell ratio of observation group were significantly lower than control group.Conclusion Pulmicort Respules combined with Tiotropium Bromide in the treatment of COPD can be targeted to the lesion site,and relieve symptoms,reduce airway inflammation,improve pulmonary function,the effect was better than simplely use Pulmicort Respules.