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The stigmatization of social system toward serious mental disorder patients is a long-standing problem,and it brings the stigma,which is prevailing throughout different patients with mental disorder.And that brought profound negative influences on the patients and their families.The patients with the stigma,they shame in social avoidance,worry about discrimination,even delay in diagnosis and treatment for various reasons,serious impact on their treatment,prognosis and quality of life.This article through the comprehensive analysis of the factors of the stigma among the patients with serious mental disorder in our country,and probes into how to reduce the stigma.
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Objective To discuss postoperative curative effect comparison of goserelin and gestrinone on endometriosis (EMT). Methods A total of 75 cases of patients with EMT, who were given EMT cystectomy of under laparoscopy, were divided into observation group (n=37 cases) and control group (n=38 cases) in accordance with different treatment meth-ods. The patients in observation group were given 3.6 mg goserelin by subcutaneous injection within 1 week upon the operation, once for every 4 weeks, for 6 times, while the patients in control group were given 2.5 mg gestrinone through the mouth within 1 week upon the operation, twice for every week for 48 times. According to the 2-year following-ups after treatment, the curative effect, reoccurrence rates, occurrence rates of untoward effect and pregnancy rates of pa-tients in two groups were observed. Results According to the 2-year following-ups after treatment, 4 and 2 cases of patients were lost to follow up, and after comparing the loss ratios of follow-up of patients in two groups, no statistical differences were appeared (χ2=0.15, P>0.05). The total efficiency of patients in observation group was much higher than that in control group, while the reoccurrence rate was much lower than that in control group (χ2=3.85, P<0.05). 9 and 6 cases of untoward effect were appeared in control group and observation group respectively, with light symptom, and after comparing the occurrence rates of untoward effect, no statistical differences were appeared (χ2=0.88,P>0.05). The suc-cessful pregnancy rate of patients in observation group after 2-year withdrawal of drugs was much higher than that in control group (χ2=4.69, P<0.05). Conclusion Compared with gestrinone, goserelin has more favorable postoperative cura-tive effect on EMT, which can obviously reduce the postoperative reoccurrence rate, and raise the successful pregnancy rate and higher security.
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Objective To investigate the levels of inflammatory cytokines in children with low absolute lymphocyte count (ALC).Methods 56 patients with low ALC as the patients group and 20 children with healthy physical examination as the control group were enrolled.Several inflammatory cytokines,namely IL-1,IL-6,IL-8 and TNF-βwere measured with enzyme linked immu-nosorbent assay(ELISA)kits.High sensitive C reactive protein(Hs-CRP)was measured by the immunoturbidimetry(ITM)kit with the automatic biochemical analyzer.Results The concentrations of IL-1,IL-6,IL-8 and TNF-βin the patients were(0.096±0.012) ng/mL,(0.118±0.026)ng/mL,(0.388 ±0.069)ng/mL and(1.256 ±0.245 )ng/mL respectively,which had no statistical differ-ences as compared with the control group(P >0.05);the concentration of HsCRP in the patients group was(5.7±2.8)mg/L,while which in the control group was(4.8±2.6)mg/L,showing no statistically significant difference between them(P >0.05).Conclusion The levels of the cytokines in low ALC patients are not increased,which may be related with the other factors.Actively using tra-ditional Chinese medicine treatment is beneficial to the recovery of disease.
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Objective To investigate the effect and severe adverse reactions of goserelin combined with mifepristone after operation for moderate and endometriosis laparoscopic conservative.Methods 68 cases with moderate to severe endometriosis diagnosed after laparoscopic conservative operation were randomly divided into the Gore Sherry Lin group and mifepristone group with 34 cases for 6 months of a course,regular follow-up.Clinical efficacy and adverse reaction for two groups were compared.Results The dysmenorrhea symptoms for two groups of patients have been alleviated,the efficiency rate was above 91％.The recurrence rate of the mifepristone group was higher than the goserelin group (14.71％ vs 2.94％,P ＜ 0.05).The cumulative pregnancy rate of mifepristone group was lower than the goserelin group (20.59％ vs 38.23 ％,P ＜ 0.05) discontinued for 1 years.The liver function damage of the goserelin group was significantly lower than the mifepristone group (2.94％ vs 23.53％,P ＜ 0.05).Conclusion It is more significance for using suppression of ovarian function after laparoscopic conservative operation for severe endometriosis.It can increase the pregnancy rate and decrease the recurrence rate.
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OBJECTIVE@#To determine the long-term effect and security of refractory schizophrenia with brain stereotaxis multi-target therapy technique.@*METHODS@#A total of 87 patients with refractory schizophrenia were treated with brain stereotaxis multi-target therapy and were followed up over 2 years. The scores of Clinical Global Impression, Brief Psychiatric Rating Scale, Positive and Negative Symptom Scale, Wechsler Adult Intelligence Scale, Wechsler Memory Scale, Actives of Daily Living, and Social Disability Screening Schedule were compared before and after the operation.@*RESULTS@#Of the 87 patients, 40 obviously improved, 24 improved, 12 improved little, 7 did not change. None grew worse, 1 died, and 3 shed. There was a significant difference in the scales before and after the operation (P<0.01). No severe complications and sequelae occurred.@*CONCLUSION@#Stereotaxic multi-target therapy is effective and safe for refractory schizophrenia. After the operation, drug therapy should be maintained and recovery of social function is helpful.