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Journal of Central South University(Medical Sciences) ; (12): 382-387, 2009.
Article in English | WPRIM | ID: wpr-814317

ABSTRACT

OBJECTIVE@#To investigate a new way to yield plenty of high purity olfactory ensheathing cells (OECs) and its biocompatibility with appropriate scaffolds.@*METHODS@#OECs were prepared from neonatal Wister rats and co-cultured with poly [LA-co-(Glc-alt-Lys)] (PLGL). Its contact angle, adherent rate, and activity rate were tested.@*RESULTS@#The contact angle of poly (D, L-lactic acid) (PDLLA) (84.5 degree+/-1.5 degree) was significantly higher than that of PLGL (52.6 degree+/-0.8 degree), the adherent rate of PLGL (80%) was significantly higher than that of the PDLLA (57%), and the activity rate of PLGL (88%) was much higher than that of the PDLLA (76%).@*CONCLUSION@#PLGL possesses better hydrophilicity and biocompatibility than PDLLA, and it can provide a better cell growth circumstance which is helpful for the effective treatment of nerve injury.


Subject(s)
Animals , Rats , Animals, Newborn , Biocompatible Materials , Cells, Cultured , Lactic Acid , Pharmacology , Nerve Regeneration , Olfactory Bulb , Cell Biology , Polyglycolic Acid , Pharmacology , Polylactic Acid-Polyglycolic Acid Copolymer , Rats, Wistar , Spinal Cord Injuries , Tissue Engineering , Methods , Tissue Scaffolds , Chemistry
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