ABSTRACT
Breast Cancer, nowadays, is the malignant tumor with the highest incidencein females.HER2 Positive Breast Canceraccounts for 20%-25% of the total, among which about 34% of patients with this type will occur brain metastasis.HER2 Positive Breast Cancer patients with brain metastasis, which seriously affects the quality of life, has a poor prognosis. Currently, surgery or radiotherapy is still the main treatment for brain metastasis. However, surgery is only applicable in localized brain metastasis, and it is obviously that terminaladverse reaction such as cognitive impairment can be causedby radiotherapy. Therefore, it is particularly important to discovery effective targeted drugs or new drug delivery methods for brain metastasis.This articlewill review the research progress of targeted therapy for brain metastases in HER2positive breast cancer.