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Objective To investigate the clinical value of independently-designed three-demensional printed navigation templates for hepatectomy in hepatic surgical oncology.Methods A retrospective study was conducted on 45 patients (including 36 males and 9 females,aged from 40 to 70 years) with hepatocelluar carcinoma treated by hepatoctomy from Department of Hepatobiliary and Intestinal Surgery of Hunan Cancer Hospital from June 2016 to June 2018.These patients were divided into observation group (patients conducted with the 3D navigation-template-aided operation,n =25) and control group (patients conducted with regular operation,n =20) according to operation approach.Virtual liver resection volume and actual liver resection volume were calculated in the observation group,and the correlationship between the volume of virtual liver resection and actual liver resection was analyzed by Pearson correlation analysis.The operative time,intraoperative blood loss,intraoperative intrahepatic duct injury and postoperative hospital stay were compared between the two groups.Results In the observation group,3D modeling was successfully completed and intrahepatic and extrahepatic duct reconstruction was successful,surgical simulation.There were no statistically significant difference between the virtual and actual resected liver volume in the observation group (P ＞ 0.05).The virtual resected liver volume was positively correlated with the actual resected liver volume (r =0.991,P ＜ 0.05).Volume of intraoperative blood loss in the observation group was lower than that in the control group [(245.1 ±22.3) ml vs.(308.6 ± 19.9) ml],and the length of hospital stay was shorter than that in the control group [(7.4 ±0.2) d vs.(8.6 ±0.4) d],the difference was statistically significant (P ＜ 0.05).There was no accidental injury of intrahepatic duct in the observation group,1 case of accidental injury of middle hepatic vein and 1 case of accidental injury of secondary branch of right hepatic vein in the control group.The AST of the observation group was significantly reduced compared with that of the control group on the 4 th and 7th days after the operation,and the difference was statistically significant (P ＜ 0.05).Conclusions 3D reconstruction of liver based on high quality MR images,can facilitate restoring the adjoint relationship between hepatic duct system and liver tumor.3D printed navigation templates effectively guide certain kinds of hepatectomy,ensure that the cutting edge at the same time protect the rest of the liver tissue,reduce bleeding and accidental damage,realize accurate tumor resection.
ABSTRACT
Objective@#To investigate the clinical value of independently-designed three-demensional printed navigation templates for hepatectomy in hepatic surgical oncology.@*Methods@#A retrospective study was conducted on 45 patients (including 36 males and 9 females, aged from 40 to 70 years) with hepatocelluar carcinoma treated by hepatoctomy from Department of Hepatobiliary and Intestinal Surgery of Hunan Cancer Hospital from June 2016 to June 2018. These patients were divided into observation group (patients conducted with the 3D navigation-template-aided operation, n=25) and control group (patients conducted with regular operation, n=20) according to operation approach. Virtual liver resection volume and actual liver resection volume were calculated in the observation group, and the correlationship between the volume of virtual liver resection and actual liver resection was analyzed by Pearson correlation analysis. The operative time, intraoperative blood loss, intraoperative intrahepatic duct injury and postoperative hospital stay were compared between the two groups.@*Results@#In the observation group, 3D modeling was successfully completed and intrahepatic and extrahepatic duct reconstruction was successful, surgical simulation. There were no statistically significant difference between the virtual and actual resected liver volume in the observation group (P>0.05). The virtual resected liver volume was positively correlated with the actual resected liver volume (r=0.991, P<0.05). Volume of intraoperative blood loss in the observation group was lower than that in the control group [(245.1±22.3) ml vs. (308.6±19.9) ml], and the length of hospital stay was shorter than that in the control group [(7.4±0.2) d vs. (8.6±0.4) d], the difference was statistically significant (P<0.05). There was no accidental injury of intrahepatic duct in the observation group, 1 case of accidental injury of middle hepatic vein and 1 case of accidental injury of secondary branch of right hepatic vein in the control group. The AST of the observation group was significantly reduced compared with that of the control group on the 4 th and 7th days after the operation, and the difference was statistically significant (P<0.05).@*Conclusions@#3D reconstruction of liver based on high quality MR images, can facilitate restoring the adjoint relationship between hepatic duct system and liver tumor. 3D printed navigation templates effectively guide certain kinds of hepatectomy, ensure that the cutting edge at the same time protect the rest of the liver tissue, reduce bleeding and accidental damage, realize accurate tumor resection.
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Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are a class of bioactive polyunsaturated fatty acids with inhibitory effects on colorectal cancer. Firstly, ω-3 PUFAs can change membrane fluidity and affect cell functions; Secondly, they can affect the activity of important proteins in cell signal transduction pathways and regulate the inflammatory mediators and the functions of immune cells in the tumor microenvironment; Finally, they can change the important molecules in the process of tumor metastasis and inhibit the colorectal cancer via suppressing cell proliferation, promoting apoptosis, enhancing antitumor immunity, and preventing tumor metastasis.
Subject(s)
Humans , Apoptosis , Cell Proliferation , Colorectal Neoplasms , Fatty Acids, Omega-3 , Tumor MicroenvironmentABSTRACT
Objective:To establish the preoperative three dimensional (3D) model of liver cancer,and to precisely match the preoperative planning with the target organs during the operation.Methods:The 3D model reconstruction based on magnetic resonance data,which was combined with virtual reality technology via HoloLens glasses,was applied in the operation of liver cancer to achieve preoperative 3D modeling and surgical planning,and to directly match it with the operative target organs during operation.Results:The 3D model reconstruction of liver cancer based on magnetic resonance data was completed.The exact match with the target organ was performed during the operation via HoloLens glasses leaded by the 3D model.Conclusion:Magnetic resonance data can be used for the 3D model reconstruction to improve preoperative assessment and accurate match during the operation.
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Objective To explore the correlation between up-regulation of cyclooxygenase-2(COX-2) (expression) and hepatocellular carcinoma(HCC) angiogenesis.Methods The expression of COX-2,vascular endothelial growth factor(VEGF)、basic fibroblast growth factor(bFGF) and angiopoientin-2(Ang-2) were examined in eighty matched sets of HCC specimens using immunohistochemistry and reverse (transcription-polymerase) chain reaction(RT-PCR).Results In HCC,the expression rate of COX-2,VEGF,bFGF and Ang-2 was 75.0%,62.5%,60.0% and 61.25%,respectively.(Immunohistochemical) staining scores of VEGF、bFGF and Ang-2 were 5.98?1.16,4.57?0.26 and(5.87)?0.12,respectively in strongly postive group of COX-2;and were 3.30?0.22,2.61?0.16 and 2.63?0.13,respectively in moderately weak postive group of COX-2.The expression rates of VEGF,(bFGF) and Ang-2 were 100.0%(95/95),94.29%(33/35) and 97.14%(34/35),respectively in strongly postive group of COX-2;and were 60.0%(15/25),60.0%(15/25) and 60.0%(15/25),respectively in moderately weak postive group of COX-2.There was significant difference in HCC(angiogenesis) between the two groups(P