ABSTRACT
@#Tumor immunotherapy is a therapeutic modality that uses immunological principles and methods to activate and enhance the body''s immune system to generate immune response for the removal of tumour cells. Many new immunotherapeutic agents have demonstrated effective anti-tumour capabilities, yet their clinical use is challenging due to the complex mechanisms of tumour immune escape. Meanwhile, these drugs would accumulate in different tissues and organs in the human body and be unable to achieve precise and specific targeting therapeutic effects, resulting in serious immune-related adverse effects, which greatly hinders the clinical potential of immunotherapy.Nanodrug delivery systems can deliver immunotherapeutic drugs to target tissues or specific immune cells precisely, thereby enhancing immune effects and reducing side effects.This paper reviews the research progress of nanodrug delivery systems in tumour immunotherapy in recent years based on the regulatory mechanism of the anti-tumour immune response, with a prospect of the challenges and development in this field.
ABSTRACT
@#随着科学技术的蓬勃发展，近年来多种新型 药物递送系统技术为解决现有药物的临床瓶颈提 供了强有力的指导。回望发展，药物 3D 打印技术 为制药行业带来新变革，将药物研发由传统工业 化生产转变成个性化设计；跨越溶酶体递送策略 推动了小核酸药物的研发与运用；以生物金属有 机框架为代表的新型纳米药物递送系统解决了许 多药物难以被高效输送到疾病部位的难题。药物 递送技术的突破和成熟为众多新型药物的临床转 化提供了推动力，目前已经被大量用于小分子化 药、核酸药、大分子蛋白药物等递送，相关的临床 前研究和临床转化正稳步推进中。本期组织了新 型药物递送系统技术在药物研发中的运用和展望 这一专题，紧跟前沿领域的最新进展，希望可以为 新药研发人员提供了一些参考与启发。