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cells, the expression of PTEN was up-regulated while pAkt down-regulated. Conclusions AS-miR-221 and AS-miR-222 may enhance the radiosensitivity of MCF-7 breast cancer cells by up-regulating the expression of PTEN.
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We have established a computer model of calculating the normal tissue complication probability (NTCP) in line with the current primary methods and have designed the relevant software. Consequently, the complex calculation becomes easy, thus facilitating the clinical use of NTCP and improving the model step by step.
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Humans , Algorithms , Probability , Radiation Injuries , Epidemiology , Radiotherapy , Radiotherapy Planning, Computer-Assisted , Software DesignABSTRACT
Objective To investigate the effect of external beam irradiation re-stenosis in form of neointimal hyperplasia following carotid endarterectomy in rabbits. Methods 144 Japanese white rabbits were divided into 24 groups, with 6 rabbits in each. All animals underwent carotid endarterectomy and were fed on hypercholesterol diet. The vessels which underwent surgery were irradiated with 6 MV photon, to a dose of 0, 6, 12, 18, 24 and 30 Gy. The animals were sacrificed on D15, 30, 60 and 90 after irradiation. The irradiated vessels were examined with histopathology and immunohistochemical methods. Results The differences in the values of neointimal area/media area, proliferating cell nuclear antigen (PCNA) stain, a-Acn'n stain and platelet-derived growth factor (PDGF) stain were all significant (P
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Objective To study the range of movement of pulmonary lesion and diaphragm in stereotactic radiotherapy for lung cancers. Methods We measured the range of movement in 48 lung cancer patients. The movement at different locations of the lung varied. The change in tumor volume from the reconstructed three dimensional (3D) images during respiration as measured by a respiratory simulator was observed. Results The movement was smaller in upper parts of lung in the X and Y directions (0.2?0.06)～(0.20?0.11 )?cm. The movement of the lower field of lung was larger than that of the upper fields (0.31?0.10)～(0.36?0.10)?cm. This is due to the heart and aortic pulsation. However, the movement was the largest in the Z direction (0.9? 0.45 )～(0.93?0.46)?cm. Moreover, if the time of computed tomography (CT) scan for each slice of lung tissue was equal to or longer than the interval of a breathing cycle, the tumor information was not lost. The reconstructed 3D images involved all the movements. The size of reconstructed 3D images changed inversely with the breathing movement. Conclusions The affection of breathing movement in lung cancer is chiefly in the Z direction. If the time of CT scan is equal to or longer than the interval of a breathing cycle, the reconstructed 3D images will encompass all the information of the tumor and its movement, showing the gross tumor volume (GTV) which does not need any safety margin. If the time of CT is shorter than the breathing cycle like the spiral CT, the reconstructed 3D image can not show the range of tumor movement.