ABSTRACT
Probiotics is important to promote the absorption of nutrients,to respond to immune response,to suppress inflammatory cytokines and so on.Premature infant white matter damage is the main pathological form of preterminfant brain injury,and it is often complicated with cognitive,hearing impairment,mental retardation,cerebral palsy,etc.The latest finding is that probiotics can ensure balanced nutrition intake,improve body immunity,inhibit inflammatory factor release,reduce nerve cell edema,enhance antioxidant enzyme activity and oxygen free radical scavenging,inhibit excitatory amino acid activity,reduce excitatory toxicity,and promote the recovery of function of nerve cells in white matter damage in premature infants through microbiota-gut-brain axis.This article reviews the protection and repair of probiotics in premature infants with white matter damage.