ABSTRACT
Dauricine ( Dau ) was studied on the pharmacokinetics in experimental acute renal failure (ARF ) induced by HgCl2 or acute liver injury ( ALI ) induced by CC14 in rabbits.After iv administration of 5 mg/kg in normal rabbits the main pharmacokinetic parameters of Dau were as follows:t1/2=0.18?0.12 (h), t1/2?=3.18?0.95 ( h ) , Vd = 26.7l? 3.61 ( L/kg ) and Cl = 6.91 ? 1.74 ( L/h?kg-1 ). The pharmacokinetic parameters of Dau in ARF were not significantly different from that in normal. Cl (3.31?1.88 L/h?kg-1 ) in ALI was significantly lower than that in normal and t1/2? ( 8.85?4.57 h ) in ALI was considerably longer than that in normal.The results indicated that the pharmacokiaetics of Dau had no change in rabbits with ARF and its elimination was prolonged in rabbits with ALI.