ABSTRACT
OBJECTIVE@#To assess the geometrical matching of a new anatomical adaptive titanium mesh cage (AA-TMC) with the endplate and its effect on cervical segmental alignment reconstruction in single- and two-level anterior cervical corpectomy and fusion (ACCF) and compare the compressive load at the endplate between the AA-TMC and the conventional titanium mesh cage (TMC).@*METHODS@#Twelve cervical cadaveric specimens were used to perform single- and two-level ACCF. The interbody angle (IBA), interbody height (IBH) and the interval between the AA-TMC and the endplate were evaluated by comparison of the pre- and postoperative X-ray images. The maximum load at the endplate was compared between the AA-TMC and TMC based on American Society for Testing and Materials (ASTM) F2267 standard.@*RESULTS@#No significant differences were found between the preoperative and postoperative IBA and IBH in either single-level ACCF (11.62°±2.67° 12.13°±0.69° and 23.90±2.18 mm 24.23±1.13 mm, respectively; > 0.05) or two-level ACCF (15.63°±5.06° 16.16°±1.05°and 42.93±3.51 mm 43.04±1.70 mm, respectively; > 0.05). The mean interval between the AA-TMC and the endplate was 0.37 ± 0.3 mm. Compared to the conventional TMC, the use of AA-TMC significantly increased the maximum load at the endplate in both single-level ACCF (719.7±5.5 N 875.8±5.2 N, < 0.05) and two-level ACCF (634.3±5.9 N 873±6.1 N, < 0.05).@*CONCLUSIONS@#The use of AA-TMC in single-level and two-level ACCF can significantly increase the maximum load at the endplate to lower the possibility of implant subsidence and allows effective reconstruction of the cervical alignment.
Subject(s)
Humans , Biomechanical Phenomena , Cervical Vertebrae , Prostheses and Implants , Spinal Fusion , Surgical Mesh , Titanium , Treatment OutcomeABSTRACT
OBJECTIVE:To investigate the incidence of adverse drug reactions(ADRs),the ratio of irrational drug use and the average daily drug costs after the initiation of clinical pharmacists' intervention on the combined use of antibiotic injections in the outpatient department.METHODS:By a controlled prospective study,500 patients in the intravenous center in outpatient department whose records were in line with inclusion criteria were included before intervention as controls,and after the initiation of clinical pharmacists' intervention on the combined use of antibiotic injection in the outpatient department,500 patients meeting the inclusion criteria were enrolled as trial group.A database was established and the results were analyzed statistically.RESULTS:The irrational drug use was noted in 52 cases in the control group versus 21 cases in the trial group and the ADRs or adverse drug events were noted in 18 cases for the control group versus 9 cases for the trial group.The daily mean drug cost reduced by 29.84 yuan after intervention.CONCLUSION:The intervention measures contributed to the reduction in incidences of irrational drug use and ADRs and drug costs.
ABSTRACT
OBJECTIVE: To analyze the chief factors influencing the adverse drug reactions (ADR) in outpatient use of antibiotics so as to formulate corresponding policies for intervention. METHODS: The patients who had been treated i.v with antibiotics from Mar. 2006 to Mar. 2007 were enrolled: 105 in trial group showed ADR, another 105 in control group showed no ADR. The ADR influencing factors were compared between the two groups from aspects of patients, nursing, and medication to find out the significant differences. RESULTS: The chief factors influencing the adverse drug reactions (ADR) in outpatient use of antibiotics included the indications of drugs, dosage, dosing interval, drug combination, and availability of medication guidance. CONCLUSION: The outpatient intravenous use of antibiotics is far from rational, which needes further intervention.
ABSTRACT
OBJECTIVE:To improve the safety of antibiotic injections in outpatient department. METHODS:In a prospective randomized control study,outpatients treated with antibiotic injections in 2007 were chosen to be the subjects. The subjects were randomized into control group and intervention group. Education,administration intervention and inspection were adopted in clinical intervention considering the factor of drug combination. The rationality of drug combination and the incidence of ADR before and after intervention were observed. RESULTS:As compared with control group,the rationality of drug combination in intervention group was improved obviously(P
ABSTRACT
OBJECTIVE:To investigate the characteristics and the prevention of traditional Chinese medicine-induced death. METHODS: The traditional Chinese medicine-induced death cases from 1994 to 2006 collected by retrieving full-text data base of CHKD were analyzed statistically. RESULTS: Of the total traditional Chinese medicine-induced death cases, drugs were chiefly administered by intravenous drip and oral administration, and allergic shock was the chief death causes. CONCLUSION: Clinicians and pharmacists should attach great importance on the ADRs induced by traditional Chinese medicines to ensure safe and effective drug use.
ABSTRACT
OBJECTIVE:To comprehend the causes for adverse drug reactions (ADR)associated with the traditional Chinese medicine injections in order to improve therapeutic safety.METHODS:Through tracking visits and retrospective study of patient cases,100 control cases and 93 ADR cases are analyzed in terms of medicine,patient,prescribing and nursing,both by single-factor and multi-factor approach.RESULTS:The main causes of ADR associated with traditional Chinese medicine injections are:overdosing,combined administration of drugs,longer-than-required time gap between dispensing and transfusion,failure to do pre-dosing liver or kidney function checkup,irrelevance of indication,lack of detailed instruction about way of administration and dosing,and lack of remarks on pharmacological action.CONCLUSION:It’s vitally important to improve prescribing and nursing behaviors for the sake of enhanced safety of clinical use of drugs.