ABSTRACT
Objective To investigate the risk factors and treatments of invasive fungal infection (IFI) in recipients who underwent liver transplantation (LT).Methods We retrospectively analyzed the frequency and characteristics of IFI in 10 recipients who received LT between January 2005 and October 2018 in Tianjin First Central Hospital and evaluated the risk factors and treatments of IFI after LT.Results Of 10 cases of IFI after LT,9 cases obtained the definite diagnosis and one case clinical diagnosis.There was one case of mucor infection,4 cases of aspergillus infection (1 case was complicated with cryptococcus neoformans infection,2 cases of cryptococcus neoformans infection (one case was complicated with aspergillus infection),and 7 cases of candida infection.The survival rate of patients with IFI was significantly reduced.Liver failure,fungal colonization,indwelling catheter,concomtant gastrointestinal bleeding,intestinal dysfunction,and long-term application of broad-spectrum antibiotics were risk factors of IFI after LT.Conclusion Of 10 cases of IFI,the oceurance of infection in 9 cases is closely related to the preoperative status.Eetiology detection is difficult and takes long time.The biopsy is still the gold standard.High-throughput sequencing can be used as a supplementary means for microbiology detection.Preoperative assessment and early reasonable antifungal drugs are effective treatment measures for IFI after LT.