ABSTRACT
Aim To explore the effect of Sanshi Shengxin Ointment on the healing of pressure wounds in rats and its mechanism. Methods The experimental animals were divided into sham operation group (Sham), model group (Model), Bei Fuxin group (bFGF), Sanshi Shengxin ointment group (TM), and Sanshi Shengxin ointmen + PI3K blocker group (TM + LY294002). The pressure ulcer rat model was prepared by the local tissue ischemia-reperfusion injury method. The wound healing rate of rats in each group was observed on 3rd, 7th, and 14th day. On 3rd day of the dressing change, the pathological changes of the wound, the plasma VEGF content, and the expression of VEGF and PI3 K/Akt signal-related proteins in the wound skin tissue were detected. Results Compared with sham group, the wound healing rate of rats in model group was reduced (P < 0. 01) with severe wound injury. The plasma VEGF content decreased (P <0. 01), and the expression of VEGF, p-PI3K, and p-Akt decreased too (P <0. 01). Compared with model group, the wound healing rate and VEGF content of rats in TM group increased (P < 0. 05 or P < 0. 01), the wound injury was significantly improved, and the expression of VEGF, p-PI3K, and p-Akt increased (P <0. 05 or P < 0. 01). Compared with TM group, the wound healing rate and the content of VEGF decreased in TM + LY294002 rats (P <0. 01), the wound injury was aggravated, and the expressions of tissue VEGF, P-PI3K, and p-Akt decreased (P < 0.05 or P < 0.01). Conclusions Sanshi Shengxin Ointment can up-regulate the expression of VEGF through PI3K/Akt signal and promote the healing of pressure sore in rats.
ABSTRACT
OBJECTIVES@#To investigate establishing, applying and evaluating the fall prevention and control information system in elderly community.@*METHODS@#Relying on internet technology and informatization means, the fall comprehensive prevention and control strategy of elderly was guided into online from offline. The fall prevention and control information system which was a collection of risk assessment, remote education and feedback was established. One hundred and twenty-six elderly (over 60 years old) in community were screened in this study and 84 high-risk elders who were involved in the remote continuous comprehensive intervention were screened out. Intervening measures included distributing propaganda album, making mission slides and video used to play with the interpretation remotely. Then fall related situation before and after intervention was analyzed and the effectiveness of system evaluated.@*RESULTS@#After remote intervention, the fall incidence of high-risk group decreased from 21.43% to 4.76%(<0.01). The body balance and gait stability improved clearly(<0. 01). The rate of taking proper prevention and control behavior significantly improved(<0.01). They believed in themselves not to fall down with more confidence when taking complex behaviors(<0.01). The security of environment at home significantly enhanced(<0. 01).@*CONCLUSIONS@#Fall prevention and control information system in elderly community was innovative and convenient. The system could roundly assess the status related to fall and accurately screen out high-risk group. The system could implement the remote continuous comprehensive intervention so that the incident of fall was decrease. In conclusion, the system is stable and effective, can be further popularization and application as a successful pilot.