ABSTRACT
leucine-rich repeat (in FLⅡ) interacting protein 1(LRRFIP1) is a kind of transcription inhibitory factor which exists in tissue cells of various animals and human body.Its expression increases significantly in epidermal growth,tumors and cerebrovascular diseases.With transcription inhibition feature,it involves in the regulation of signal pathways and the platelet cytoskeleton component.It is also target gene of miRNA regulation and plays an important role in the process.This paper reviews the LRRFIP1 structure characteristics,distribution and function and its regulation mechanism.
ABSTRACT
@# ObjectiveTo study the effect of topiramate on the expression of Heat Shock Protein 70 (HSP70) after brain ischemia and reperfusion injury.MethodsWistar rats were performed operation of double renal artery stenosis to make hypertension. 2 months after, the rats were separated into 3 groups randomly: topiramate group,ischemic reperfusion group and fake operation control group. The rats were performed operation of middle cerebral artery occlusion (MCAO) and made them in ischemia for 2 h. One day later, their brains were obtained, and the number of positive and negtive cells were counted by computerized pathological image analyzer.ResultsThe HSP70 expression of topiramate group was higher than that of ischemic reperfusion group(P<0.05).No positive cell had been found in the samples of the control group.ConclusionTopiramate can enhance the expression of HSP70 and may therefore protect the ischemic brain tissue from reperfusion injury.