ABSTRACT
Objective To observe the clinical effect of zoledronate in patients with osteoporosis and its influence on the indicator of bone metabolism.Methods 120 cases osteoporosis patients were randomly divided into treatment group (66 cases) and control group (54 cases).Control group were given calcium carbonate vitamin D3 ,patients in treatment group were also treated with zoledronate by intravenous injection.The pain score, bone density and the indicators of bone metabolism one year after the treatment were analyzed and compared.Results After one year of treatment, the pain score of treatment group was significantly lower than that of the control group, showing significant difference between the two group(P<0.05). Bone density of L1-L4, neck were higher than those of control group, serum concentrations of BALP,β-CTX, DPD/Cr were lower than that of control group(all P<0.05), but hCT was lower than that of control group(P<0.05), and the treatment of serum Ca,P,BGP were not significant statistically before and after treatment.In treatment group, serum TRACP-5b was remarkably decreased, but was increased remarkably in control group(P<0.05) .Conclusion Zoledronate combined with calcium carbonate vitamin D3 in treatment of patients with osteoporosis can be effective in improving the symptom of pain associated with bone metabolism indicators, decrease bone absorb, increase the bone mineral density, with less adverse reaction and patient compliance is good.