Clinical features of patients with systemic lupus erythematosus complicating hepatitis B virus infection / 中华风湿病学杂志

Objective To investigate the clinical features of patients with systemic lupus erythematosus (SLE) complicating with hepatitis B virus (HBV) infection.Methods The medical records of 40 inpatients with SLE complicating with HBV infection and 60 SLE inpatients without HBV infection were analyzed retrospectively.Chi-square test and t test were used for statistical analysis.Results Forty patients with SLE complicating with HBV infection were included,including 4 men and 36 women,with the mean age of (32±13) yr.Twenty-three patients suffered from chronic HBV hepatitis,5 patients were serological HBsAg carriers,12 patients with HBV occult infection.Twenty-one patients had mild liver dysfunction,presented mainly as increased ALT,2 patients presented with severe liver function abnormality.The main types of lupus rlephritis were Class Ⅳ and Class Ⅴ,2 patients complicating with HBV-associated glomerulonephritis.Compared with the control group,patients with SLE complicating with HBV infection had a significantly higher prevalence of fever,liver involvement,renal lesion,thrombocytopenia and cytomegalovirus infection respectively.One patient with severe liver abnormality had poor prognosis.Conclusion More attention should be paid to the clinical features of SLE complicating with HBV infection.Patients with SLE complicating with HBV infection have a significantly higher prevalence of fever,liver involvement,renal lesion,thrombocytopenia and cytomegalovirus infection respectively.Patients with SLE complicating with HBV infection may suffer from HBV-associated glomerulonephritis.Severe liver abnormality predicts poor prognosis.Anti-HBV drugs should be prescribed for SLE patients with serological positive HBsAg while immunosuppressive agents are used.

Study on Systemic Lupus Erythematosus Induced by Sunlight / 中国医师杂志

Objective To explore the clinical features of systemic lupus erythematosus (SLE) induced by sunlight.Methods The clinical data of 52 patients with SLE induced by sunlight and 40 SLE patients without photosensitivity were analyzed. Results Compared with SLE patients without photosensitivity, malar rash and anti-ds-DNA antibody in patients with SLE induced by sunlight were more common,which pleuritis, pericarditis, renal disorder and hemolytic anemia were less frequency. There were not significant differences in oral ulcers, arthritis, neurologic disorder, leukopenia, positive anti-Sm antibody and antinuclear antibody between the two groups patients. Conclusion We should pay more attention to the clinical features of SLE induced by sunlight.