ABSTRACT
Objective:To explore the multivariate logistic regression analysis and imaging characteristics of chronic obstructive pulmonary disease (COPD) with invasive pulmonary aspergillosis.Methods:From February 2017 to February 2019, 73 patients with COPD complicated with invasive pulmonary aspergillosis admitted to the Hangzhou Dajiangdong Hospital were selected as observation group, and 81 COPD patients without invasive pulmonary aspergillosis admitted to the Hangzhou Dajiangdong Hospital from February 2017 to February 2019 were selected as control group.Multivariate logistic regression analysis was used to analyze the independent risk factors of COPD with invasive pulmonary aspergillosis, and to observe the imaging characteristics of COPD with invasive pulmonary aspergillosis.Results:Univariate analysis showed that there were no statistically significant differences in sex, age, course of disease, combined with underlying diseases and smoking history between the two groups (all P>0.05); there were statistically significant differences in long-term hormone use, hypoproteinemia, long-term antibiotics use and invasive operation between the two groups (χ 2=32.372, 16.593, 36.671, 21.566, all P<0.05). The results of logistic regression analysis showed that long-term use of hormones, hypoproteinemia, antibiotics and invasive manipulation were independent risk factors for COPD complicated with invasive pulmonary aspergillosis ( OR=1.685, 95% CI: 1.208-2.142, OR=2.546, 95% CI: 1.682-3.981, OR=2.984, 95% CI: 1.982-4.653, OR=2.109, 95% CI: 1.462-3.241, all P<0.05). The main clinical manifestations of COPD with invasive pulmonary aspergillosis were cough, sputum, chest pain and dyspnea.The main imaging manifestation of COPD with invasive pulmonary aspergillosis was non-specific infiltration, accounting for 50.68%(37/73). Conclusion:COPD complicated with invasive pulmonary aspergillosis is affected by many factors.The main clinical manifestations are cough, sputum, chest pain and dyspnea, and the main imaging manifestation is non-specific infiltration shadow.