Clinical Efficacy and Safety of Adapalene0.1%Gel with Individualized Treatment Regimen for Acne Vulgaris / 中华皮肤科杂志

Objective To evaluate the clinical efficacy and safety of adapalene0.1%gel with individ-ualized treatment regimen for acne vulgaris(ITRAV).Methods Eighty-one patients with acne vulgaris of mild to moderate severity were treated with adapalene0.1%gel topically1to3times daily for6to8weeks according to the severity of the disease.Clinical responses were recorded and photographed weekly in30pa-tients randomly selected from the81patients,and treatment regimens were adjusted accordingly.Results It was shown that cure rates were44.4%and73.4%,in81recruited cases and30selected cases,respectively.Seborrhea decreased remarkably(83.3%)in the treatment.Side effects took place in39.5%of patients with-out interruption of the treatment.Conclusions ITRAV with adapalene0.1%gel has been proved to have an excellent response.Reasonably increasing the daily dosage could improve the cure rates.The cutaneous tolera-bility of the drug was generally good.Seborrhea could be reduced considerably during the treatment

Basidiobolomycosis:A Case Report and Its Ultrastructural Changes / 中华皮肤科杂志

A patient with basidiobolomycosis is reported,the clinical course described,the ultra- structural and histologic changes observed,and mycologic examination was made.The results indicated that:(1)In the course of using corticosteroids,because the inflammatory reaction was suppressed par- tially,the clinical manifestation was relatively relieved.In the loci the pathogenic fungi still grew well, and focal dissemination was observed;(2) In the course of using itraconazole,the drug exerted fungistatic and fungicidal action through the destruction of cell membranes of fungi.Meanwhile,itra- conazole also exerted a synergistic action with the defense function of the human body,resulting in an enhanced therapeutic effects.The strong acute inflammatory reaction was triggered by the destroyed fungi caused by itraconazole.Then the fungi were cleared,the lesions were absorbed and repaired.Sur- gical intervention may be helpful to remove abscesses and fibrous nodules formed in the clinical course, so as to shorten the course of treatment.