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Objective: To collect, compare and analyze the changes in the strength and stability of the forearm Rou-Kneading manipulation before and after the training in Shaolin Neigong (internal Qigong). Methods: Ninety first-year undergraduates were randomized into three groups using the random number table method, with 30 people in each group. The Gongfa (Qigong method) group received training in both Shaolin Neigong and forearm Rou-Kneading manipulation. The manipulation group only received training in forearm Rou-Kneading manipulation. The control group only received training in forearm Rou-Kneading manipulation for one week. The ZTC-1 intelligent Tuina (Chinese therapeutic massage) manipulation parameter detection system was used to collect the wave crest, wave trough, and crest-trough difference of the strength and frequency of the forearm Rou-Kneading manipulation on the Z-axis (up and down), X-axis (left and right) and Y-axis (backward and forward) at weeks one, five and ten from the three groups. The collected data were then processed and analyzed. Results: The intra-group comparisons showed statistical significance in the Gongfa group and manipulation group (P<0.05). The strength and stability shown on the axes Z, X, and Y constantly grew with the increase of training time in the Gongfa group. The wave crest on the axes Z and Y steadily rose in the manipulation group, as well as the frequency on the axes Z, X and Y. The control group failed to show statistical significance in any of the three times of intra-group comparisons (P>0.05). The between-group comparisons showed statistical significance among the three groups at weeks five and ten (P<0.05). At week five, the wave crest on the axes Z, X, and Y, and the crest-trough difference on the axes X and Y were more prominent in the Gongfa group than in the manipulation group, showing statistical significance (P<0.05). At week ten, the wave crest, wave trough, and crest-trough differences on the axes Z, X, and Y were more prominent in the Gongfa group than in the manipulation group, presenting statistical significance (P<0.05). Conclusion: Practicing Shaolin Neigong can help the trainees reach the level of strength and frequency of Tuina clinicians in a shorter time in the forearm Rou-Kneading manipulation training. It can advance the efficiency in studying the forearm Rou-Kneading manipulation and promote the quality of the manipulation.
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The dummy template molecularly imprinted polymers not only has such characteristics of normal imprinted polymers as rapid identification, easy preparation, stable structure and multiple reuse, but also can imprint the compounds in natural products that are not suitable as direct template. Therefore, it has drawn more and more attention in the field of the study of natural products. This paper summarizes the methods for the selection of dummy template molecules by investigating the relevant literatures in the past ten years, analyzes the advantages and disadvantages of dummy template molecules in the practical application, and based on the types of natural products active ingredients, this paper is the first to review of the latest progress in extraction and separation of dummy template molecularly imprinted polymers. We believed that this paper could provide references for better applications of the dummy template molecularly imprinted polymers to extract and separate natural products.
Subject(s)
Biological Products/chemistry , Chemical Fractionation , Molecular Imprinting , PolymersABSTRACT
To evaluate the efficiency and safety between Wenxin Granule and antiarrhythmic drugs in the treatment of atrial fibrillation(AF). A total of 8 major electronic databases(CNKI, WanFang, VIP, CBM, Cochrane Library, Web of Science, PubMed, EMbase) were retrieved since the establishment of the database to January 10, 2019. Two reviewers extracted data, and assessed the methodological quality of the included studies. The Meta-analysis was made by RevMan 5.3 software. Finally, 42 studies involving 4 657 patients were included. The results of Meta-analysis showed that compared with antiarrhythmic drug, the combined administration with Wenxin Granule and antiarrhythmic drug had a better clinical efficiency(OR=3.37, 95%CI[2.69,4.22],I~2=0%,P<0.000 01)and efficacy on cardioversion(OR=2.32,95%CI[1.67,3.22],I~2=0%,P<0.000 01), with reduction in P_d(MD=-5.48,95%CI [-7.32,-3.64],I~2=0%,P<0.000 01)and P_(max)(MD=-9.91,95%CI[-12.86,-6.95],I~2=0%,P<0.000 01). The comparison between the combined application with Wenxin Granule and the single application of amiodarone showed a clinical efficiency(OR=2.89,95%CI[1.96,4.26],I~2=44%,P<0.000 01),and efficacy on sinus rhythm maintenance(OR=2.58,95%CI[1.82,3.66],I~2=3%,P<0.000 01). The comparison between the combined application with Wenxin Granule and the single application of amiodarone showed a clinical efficiency(OR=0.88,95%CI[0.53,1.46],I~2=0%,P=0.63). The combined treatment with Wenxin Granule has a better clinical efficiency in AF better than amiodarone, with no evidence for more benefits from the single administration with Wenxin Granules.
Subject(s)
Humans , Anti-Arrhythmia Agents , Pharmacology , Atrial Fibrillation , Drug Therapy , Combined Modality Therapy , Drugs, Chinese Herbal , Pharmacology , Electric CountershockABSTRACT
Objective:To observe the effect of tuina exercise on simple obesity in college students.Methods:Fifty-seven college students with simple obesity were divided into two groups according to the stratified randomization method.Twenty-eight in the tuina exercise group were trained in tuina exercise;while 29 in the auricular acupoint sticking group were treated with acuricular acupoint sticking.The tuina exercise group was trained once every other day,and 10 times made one course.The auricular acupoint sticking was replaced once every 4 d,and 5 times made one course.After 2-course treatment,the total therapeutic effect,weight,body mass index (BMI),waist and hip circumferences,serum total cholesterol (TC),triglyceride (TG),high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were assessed.Results:The total therapeutic effect was 86.2％ in the auricular acupoint sticking group and 85.7％ in the tuina exercise group.There was no significant difference between the two groups (P＞0.05).After treatment,the weight,BMI,waist and hip circumferences were decreased and the differences were statistically significant (all P＜0.05).The waist and hip circumferences in the tuina exercise group were lower than those in the auricular acupoint sticking group,showing statistically significant differences (all P＜0.05).After treatment,there were no significant intra-group differences in TC,TG,HDL-C and LDL-C in the two groups (all P＞0.05),and the between-group differences were not significant (all P＞0.05).Conclusion:Tuina exercise has reliable effect in treating obesity.It can produce more significant improvements in waist and hip circumferences than auricular acupoint sticking.But no obvious effect is shown in blood lipid indicators.
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Objectives: To investigate the relationship between helicobacter pylori (Hp) infection and carotid intima thickness. Methods: We searched the databases of Pubmed, Embase, CNKI, VIP and Wanfang for published studies on the relationship between Hp infection and carotid intima thickness in China and abroad. 2 reviewers independently identified and enrolled the articles, extracted specific data and assessed the quality of reference by Jadad scale. Meta-analysis was conducted by Stata 12.0 Software. Results: A total of 9 case-control studies were enrolled, all the reference quality scores≥4 which included 694 subjects with Hp positive and 676 with Hp negative. Meta-analysis indicated that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects, standard mean difference (SMD)=0.803, 95% CI(0.686-0.919), P<0.05. Age related study presented that carotid intima thickness was higher in Hp positive subjects than Hp negative subjects at the age≥60 years'population, SMD=1.296, 95%CI (1.125-1.467), P<0.05; carotid intima thickness was also higher in Hp positive subjects than Hp negative subjects at the age<60 years'population, SMD=0.379, 95%CI (0.220-0.537), P<0.05. Conclusions: Hp infection has been related to the thickness of carotid intima and it could make carotid artery intima thickening.
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Objective To systematically evaluate the effect of metformin on the prognosis of diabetic patients combined with gynecologic cancer.Methods The database including PubMed,Embase,CNKI and Wangfang,were electronically searched with no language restriction from their inception to March 2017 to collect the studies about the effect of metformin on the prognosis of diabetic patients combined with gynecologic cancer.The references in reviews were also searched.According to the inclusion and exclusion criteria,two reviewers screened the literatures independently,extracted data and assessed methodological quality by the Newcastle-Ottawa scale.The primary end points included overall survival (OS) and progress free survival (PFS).The outcome measures were the pooled hazard ratios (HR) and 9596 confidence intervals (9596 CI).I2 was performed in a heterogeneity assessment.Publication bias was evaluated by using Begg's funnel plot and Egger's test,and the sensitivity analysis was conducted to confirm robustness.The Meta-analysis was performed using STATA 12.0 software.Results Sixteen eligible retrospective cohort studies were included and the score of quality assessment were ranged from 6 to 9.The Meta-analysis showed that metformin could improve the OS of diabetic patients with gynecologic tumors (HR=0.71,95％CI 0.59-0.85,P=0.000).Subgroup analysis revealed that metformin could improve the OS of diabetic patients combined with endometrial cancer (HR=0.70,95％CI 0.54-0.89,P=0.004) and diabetic patients combined with cervical cancer (HR=0.95,95％CI 0.90-1.00,P=0.048).Meanwhile metformin improved the OS (HR=0.56,95％CI 0.38-0.83,P=0.004) and PFS (HR=0.45,95％CI 0.30-0.68,P=0.000) of diabetic patients with ovarian cancer after adjusting for confounders.Conclusions The use of metformin is positive for the prognosis of diabetic patients combined with gynecologic cancer.It may improve the OS of diabetic patients with endometrial cancer and diabetic patients with cervical cancer.In addition,it improves the OS and PFS of diabetic patients with ovarian cancer.