ABSTRACT
Present investigation concern with combination of two drugs for the treatment of gout. One of these drug [naproxen sodium] is pain killer which is sustain their action within the body for 12 hours and the other drug [colchicine] is anti-gout, which release as conventional dosage. After oral administration naproxen will act as sustain release dosage and increase patient compliance about six batches of tablet were developed and evaluate .For the sustain release action polymers Methocel K4M and HPMCK15were used. These polymers were used in combination used with other inactive ingredients. Two methods were used for proration of final tablets. In 1[st] method only naproxen sodium granules were prepared which are sustained released. In second method these granules were mixed with colchicines powder and other all inactive ingredients. This method is easy and cost effective characterization of pallets and final tablets were performed. Final tablets were evaluated for all tests like appearance, friability, dissolution, hardness, assay, weight variation and in-vitro release study performed. The results obtained were satisfactory and complies with USP specification. Formulation containing combination of Methocel K4M and HPMC K15 showed good sustain release profile for 12 hours
ABSTRACT
The aim of study is to identify the antimicrobial property of ginger. Phytochemical screening of chloroform plant extract showed presence of different chemicals. In this study we used Cultures of E. Coli, Bacillus subtilis, Staphylococcus aureus and Streptococcus faecalis to identify the antimicrobial strength. Effectiveness of ginger against different conditions attributed to its different constitu-ents (volatile oils, shogaols, Gingerols and diarylheptanoids) that show their therapeutic efficacy by modulating the genetic or metabolic activities of our body. In this study, we performed phytochemical evaluation and antimicrobial assay of ginger root extract which were available in our local farms of Lahore. Ginger possesses a noticeable antimicrobial activity which was confirmed by checking the susceptibility of different strains of bacteria and fungus by measuring the zone of inhibition. In the light of several socioeconomic factors of Pakistan mainly poverty and poor hygienic condition, present study encourages the use of spices as alternative or supplementary medicine to reduce the burden of high cost, side effects and progressively increasing drug resistance of pathogens.
ABSTRACT
Cardiac rate analysis is constituted as one of the most essential parts of physiological patient monitoring. In this research paper, it has been investigated that electrical impedance plethysmography is the most conducive technique for this purpose. It is perceptible that the artery closest to the epidermis will generate a precise reading and for that purpose, we have designed an efficient non-invasive model based on a tetra-electrode setup placed in contact with the stratum corneum of the skin. By varying electrode size and the distance between the electrodes we can efficiently judge the point where the electric field reaches the artery. The simulation of this model is carried out by Comsol Multiphysics.
ABSTRACT
This paper illustrates the design and implementation of ECG telemetry system used to automatically estimate the dream time of a health subject. The dream time estimation has been done by acquiring variance of heart rate variability in sleep cycle. The implemented system has low power consumption and of small size [2.5cm x 3cm]. Using ECG telemetry system, the estimation of dream time is easier and faster than conventional method such as polysomnography by EEC, EMG or EOG. The experimental results enlighten that the subject experienced the dream 4 times in the whole night and by adding the time of each stage we will achieve the total dream time. The total dream time is 500 second. Compare it with commercial product shows the 2.91% error in result