ABSTRACT
Background: Postoperative nausea and vomiting is reduced if inj Dexamethasone is given preoperatively in patient undergoing Laparoscopic Cholecystectomy. The aim of this prospective randomized, controlled trial was to look into effectiveness of dexamethasone before surgery may improve nausea, vomiting after surgery in patients undergoing laparoscopic cholecystectomy
Study Design: Prospective randomized study
Setting: Department of Surgery, King Edward Medical University, Lahore - Pakistan. Period: Nov 2010 to April 2012
Methods: 138 Patients with Laparoscopic Cholecystectomy were randomized to receive 08 mg Dexamethasone [n=66] or placebo [n=72] intravenously before surgery. Seven patients were excluded on account of already on steroid treatment due to various reason. Vomiting and nausea were seen in next 24 hours after operation. Dexamethasone has minimal side effect after single dose administration. Six patients [12%] has nausea and vomiting in treatment group while 26 [47%] in the control group [p<0.001]. Patient having dexamethasone, five [10%] need antiemitics as compare to 24 [44%] of those receiving placebo [p<0.001]
Conclusion: Single dose of Inj Dexamethasone given preoperatively reduce nausea and vomiting markedly in Laparoscopic Cholecystectomy and may be routinely used in Laparoscopic procedure
ABSTRACT
Objectives: the purpose of this prospective randomized clinical study was to compare the outcome regarding pain and recurrence following Lichtenstein repair with Modified Kugel repair of inguinal hernias
Study Design: this was a prospective randomized clinical study
Materials and Methods: patients with inguinal hernia who were treated during Sep. 2010 to May 2012 using Preperitoneal Modified Kugel approach [PP group, n: 89] and the Anterior Lichtenstein approach [AL group n:87]. The operation time, hospital stay, postoperative complications and recurrence after surgery were assessed and compared statistically in both groups
Results: a total of 176 patients [173 men and 03 women] randomized to either group PP or group AL. No significant differences were observed regarding seroma and infection in both groups, however postoperative hematoma and operative time were higher in AL Group without any statistical significance [p< 0.098].The rate of recurrence and pain were significantly high with in AL group versus PP Group during period of follow up time [23.34 +/- 1.07 months Vs 23.01 +/- 0.13 months in group PP and AL respectively]. The operative time in Preperitoneal Modified Kugel Repair [PP Group] was 45.16 +/- 10.14 minutes and 52.34 +/- 07.04 minutes for Anterior Lichtenstein Repair [AL Group]
Conclusion: modified Kugel Repair of Inguinal Hernia is minimal invasive method and as safe as Anterior approach with less recurrence and pain than Lichtenstein operation