Ameliorative effects of curcumin and caffeic acid against short term exposure of waterpipe tobacco smoking on lung, heart and kidney in mice / 대한해부학회지

This study aims to evaluate the chemopreventive activity of two antioxidants (curcumin [CUM] and caffeic acid [CAF]), focusing on how these antioxidants could reduce cytotoxicity induced by short term secondhand exposure of waterpipe tobacco smoking. Forty-eight adult male BALB/c albino mice were equally divided into four groups. Antioxidants were delivered intraperitoneally, and the exposure to waterpipe smoking (WPS) was performed using a smoking machine. This experiment lasts for 14 consecutive days. Serum were collected from mice before dissection to quantify the activity of some liver enzymes, kidney function tests and proinflammatory cytokines. Lung, heart, and kidney were isolated and processed for light microscopy technique. Parallel treatment of CUM or CAF along with exposure to WPS showed less inflammation, less vacuolized, and more inflated alveoli, less deteriorations in cortex part of kidney, and less disintegration of cardiac myofibers in comparison to waterpipe only. Besides, CUM and CAF significantly reduced the activity of aspartate aminotransferase and proinflammatory cytokines. CUM and CAF were found to have anti-inflammatory and ameliorative effects against the cytotoxicity induced by exposure to waterpipe tobacco smoking, and CUM showed better chemopreventive activity than CAF.

Ameliorative effects of curcumin and caffeic acid against short term exposure of waterpipe tobacco smoking on lung, heart and kidney in mice / 대한해부학회지

This study aims to evaluate the chemopreventive activity of two antioxidants (curcumin [CUM] and caffeic acid [CAF]), focusing on how these antioxidants could reduce cytotoxicity induced by short term secondhand exposure of waterpipe tobacco smoking. Forty-eight adult male BALB/c albino mice were equally divided into four groups. Antioxidants were delivered intraperitoneally, and the exposure to waterpipe smoking (WPS) was performed using a smoking machine. This experiment lasts for 14 consecutive days. Serum were collected from mice before dissection to quantify the activity of some liver enzymes, kidney function tests and proinflammatory cytokines. Lung, heart, and kidney were isolated and processed for light microscopy technique. Parallel treatment of CUM or CAF along with exposure to WPS showed less inflammation, less vacuolized, and more inflated alveoli, less deteriorations in cortex part of kidney, and less disintegration of cardiac myofibers in comparison to waterpipe only. Besides, CUM and CAF significantly reduced the activity of aspartate aminotransferase and proinflammatory cytokines. CUM and CAF were found to have anti-inflammatory and ameliorative effects against the cytotoxicity induced by exposure to waterpipe tobacco smoking, and CUM showed better chemopreventive activity than CAF.

Acute appendicitis in a woman with eclampsia complicated by a stroke at 28 weeks gestation: a case report

Eclampsia is defined as the occurrence of one or more convulsions superimposed on pre-eclampsia. Pre-eclampsia is pregnancy-induced hypertension in association with proteinuria >0.3g in 24 hours and virtually any organ system may be affected. In eclampsia, the case fatality rate has been reported as 1.8% and a further 35% of women experience a major complication. Acute appendicitis in pregnancy is not frequently encountered [0.05-0.13% pregnancies]. This condition is associated with delayed diagnosis and management. We report a 20-year-old Afghani primigravida, who presented at 28 weeks with multiple eclamptic fits at home and fever. Caesarean section was performed. The baby was stillborn with features of intra-uterine growth restriction. Her appendix was acutely inflamed and appendectomy was done. She sustained a minor stroke but recovered completely.

Diagnosis of intracavitary uterine diseases in postmenopausal women by hysteroscopy

To reveal the hysteroscopic findings among postmenopausal women who were subjected to diagnostic hysteroscopy method. This is a descriptive study which was conducted at King Hussein Medical Center within the period from January 2008 to January 2010, on a total of 215 postmenopausal women. Mean age of the study group was 58 years [range 46-70]. Hysteroscopy was carried out to detect intracavitary disease, either by hysteroscopic view or using histopathological biopsies for other diseases. Simple descriptive statistics [frequency, mean age and percentage] were used to describe the study variables. The histopathological and hysteroscopic findings were as follows: polyps in 122 [56.7%] patients, atrophic endometrium in 44 [20.5%] patients, synechia in 22 [10.2%] patients, fibroid in 13 [4.6%] patients, endometrial hyperplasia in seven [3.3%] patients, focal thickening seven [3.3%] patients. The most frequent findings at hysteroscopy for postmenopausal women with bleeding were benign lesions. Hysteroscopy using biopsy is a selective method for detecting intracavitary uterine disease

Efficacy of combined local anesthetic wound infiltration and paracetamol suppositories in relieving postoperative pain in children

To evaluate the efficacy of combined incisional infiltration with Bupivacine and Paracetamol suppositories with Paracetamol suppositories alone in relieving the postoperative pain associated with surgery of inguinal pathologies. Prospectively, on hundred and ten children whom underwent groin surgery at Prince Rashed Ben Al-Hassan hospital form April 1, 2008 to December 1, 2008 were included in the study. Their ages ranged from six months to 13 years. Surgery was performed under general anesthesia. Patients were randomized into two groups; group A [55 patients] received Paracetamol rectally 30 mg/kg immediately preoperatively, while group B [55 patients] had Paracetamol rectally 30mg/kg and incisional wound infiltration with Bupivacaine 1 mg/kg. Post operative pain was managed by giving Paracetamol. The duration of the postoperative analgesia was estimated based on the time when rescue analgesia was first given. Assessment of the quality of postoperative analgesia was based on the children's behavior. In our study, both parents and older children were willing to cooperate. None of the children in the study groups suffered from local anesthetic toxicity such as arrhythmias, seizures, allergy and hematoma or tissue edema. In group A, 15 children suffered pain in the recovery room and received further analgesia in the form of Paracetamol suppositories, 18 had pain and received analgesia at home within four to six hours after discharge. The remaining 22 suffered pain during the next five days after surgery. In group B, two patients had pain in the recovery room, eight had pain with early mobilization at home and had their first analgesic dose after five to eight hours. The other 45 children had no significant post-operative pain. Group B showed an increased duration of postoperative analgesia with early mobilization. Rescue mean time at which children had their first post-operative dose of analgesia was two to four hours in group A and it was five to eight hours in group B. No patient in group B needed analgesia after day three post-operatively. Wound infiltration with Bupivacaine 1mg.kg combined with rectal Paracetamol 20 mg/kg has a better and valuable efficacy compared to the rectal Paracetamol 30mg/kg alone with respect to providing pain relief following inguinal herniotomy, hydrocelectomy and orchidopexy in children, with a longer duration of pain relief and earlier mobilization