ABSTRACT
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck region. NPC has the characteristics of insidious onset, strong invasiveness and early lymph node metastasis. A variety of signaling pathways play a role in the invasion and metastasis of nasopharyngeal carcinoma, but the specific mechanism has not yet been fully elucidated. Recent studies have found that DNA methylation of nasopharyngeal carcinoma-related genes can affect the invasion and metastasis of nasopharyngeal carcinoma through a variety of signaling pathways including Wnt/β-catenin, PI3K/AKT and MAPK signaling pathways. This article reviews the specific mechanism of DNA methylation affecting the invasion and metastasis of nasopharyngeal carcinoma through the above-mentioned signaling pathways.
ABSTRACT
Matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) is a kind of the latest mass spectrometry,which has many advantages including high throughput,rapidity,excellent repeatability and high sensitivity.It has been an important tool for both the research and clinical application in lung cancer and has an optimistic prospect in the many fields,such as early diagnosis,screening and evaluation of therapeutic effect.