ABSTRACT
Practice, an important part of medical teaching happened in hospitals, is difficult to be included in the diagnosis and improvement system of schools. Therefore, Jiangxi medical college has established the "five-point and seven-line" diagnosis and improvement system in practice teaching and promoted its implementation according to the idea of "emphasis on key points, point to string transformation, problem-oriented approach, continuous improvement, comprehensive promotion and stratified diagnosis and reform". Through two years' practice, some achievements have been made in the practice teaching management, the improvement of the basic knowledge of interns, the enhancement of teaching and learning consciousness and so on. The achievements have further promoted the cultivation of the concepts of diagnosis and reform of both schools and hospitals, and facilitated the efficiency of practice management and the quality of practice teaching.
ABSTRACT
Objective To prepare scutellarin liposomes and to investigate the pharmacokinetics in rats. Methods The liposomes of scutellarin coated with carbopol were prepared with the film dispersion method.Minicolumn centrifugation method was applied to measure the encapsulation efficiency (EE) before and after coating. SD rats were randomly divided into three groups, which were given intragastric administration of scutellarin suspension, scutellarin liposomes, and carbopol-coated scutellarin liposomes, respectively. And then the pharmacokinetic parameters were compared. Results Carbopol-coated scutellarin liposomes after intragastric administration in rats showed pharmacokinetic characteristics of two-compartment model. The main pharmacokinetic parameters of scutellarin suspension,scutellarin liposomes,and carbopol-coated scutellarin liposomes were as follows:AUC0-∞(50.03±13.45) μg?h?mL-1 ,(78.99±20.28) μg?h?mL-1 ,and (107.97±27.26) μg?h?mL-1 , respectively. Conclusion After coated liposomes, the oral bioavailability of scutellarin 1iposomes can be significantly improved,and the maximum drug concentration also increased.
ABSTRACT
At present,diagnosis and improvement of teaching quality in higher vocational colleges mainly depends on the internal quality assurance system shaped by "five vertical,five horizontal and one platform".Practical teaching is of great importance to medical education.As its teaching quality is mainly generated from the hospitals which are difficult to be integrated with the existing internal quality assurance system.This article tries to build a diagnosis and improvement system for training interns through a method focusing on "five elements and seven ways of giving feedback" on the basis of the in-depth analysis of factors generating the quality of intern training.This system aims to continuously ensure the quality of interns training via supplementing and perfecting the existing internal quality system of medical colleges.
ABSTRACT
This study aimed at optimizing the extraction process of Bi Xie Fen Qing (BXFQ) drink using ultrasound-microwave cooperation with central composite design-response surface method in comparison with the traditional decoction process.Taking microwave frequency,amount of water,extraction time as the main detection factors,diosgenin,glycyrrhizic acid and the extract yield were tested as the evaluation indexes;and taking an integrated score as response value for response surface and contour,predictive analysis was carried out and the optimum extraction conditions were achieved.It was found that the optimum extraction process of BXFQ drink was identified:the microwave frequency was 434 W,water addition was 18.4 times,extraction time was 9.3 mins and the ultrasonic frequency was fixed at 50 W.Under the optimum process,the diosgenin extraction yield rate was 23.17％ (mg· g-1),extraction yield rate of glycyrrhizic acid was 0.64％ (g·g-1),and the extraction yield rate of extractum was 34.12％ (g·g-1).All the indexes were superior to those of the traditional method.It is concluded that the composite design-response surface method is suitable for the extraction optimization of BXFQ drink with favorable predictability of the mathematical model.The optimized ultrasoundmicrowave cooperation was easy to operate with high extraction efficiency.It is suitable for industrialized production with the provision of a scientific reference for the modern formulation development of BXFQ drink.