Adiponectin is a good marker for metabolic state among type 1 diabetes mellitus patients

Adiponectin is secreted from adipose tissue. This hormone has a fundamental role in pathogenesis of insulin resistance, and has anti-inflammatory and anti-atherogenic effects. The objectives of this study were to compare serum adiponectin level between type 1 diabetics and healthy people and to assess its related factors, and also to determine the relationship between adiponectin and metabolic state. This was a case control study involving 60 diabetics [25 good and 35 poor metabolic controlled] and 28 healthy persons [younger than 18 years old]. The data about demographic [age and sex], clinical and paraclinical characteristics [body mass index [BMI], duration of disease, puberty state, and glycosylated hemoglobin [HbA1c] and adiponectin level in serum] were collected. Determinants of adiponectin were assessed using univariate and multiple linear regression analyses. Mean [ +/- SD] serum adiponectin level in healthy persons, good-controlled and poor-controlled type 1 diabetes mellitus patients were 9.16 [ +/- 4.2] microg/cc, 10.89 [ +/- 4.48[microg/cc, and 15.92 [ +/- 8.26]microg/cc, respectively. Post hoc analysis revealed that differences of adiponectin between poor- and good-controlled type 1 diabetes mellitus patients [P=0.01] and between healthy persons and poor controlled type 1 diabetes mellitus [P<0.0001] were statistically significant. Adiponectin level was associated with puberty state and BMI in healthy persons. It was associated with puberty state and HbA1c in type 1 diabetic persons. Serum level of adiponectin was higher in type 1 diabetics than in healthy persons and it can be used as a good marker for metabolic control state among diabetics

Does congenital hypothyroidism have different etiologies in Iran?

To determine the prevalence of congenital hypothyroidism [CH], permanent and transient CH. From November 2006 to September 2007, 63031 newborns were screened by measuring serum TSH obtained by heel prick. The neonates who had a TSH>/=5mU/L were recalled for measurement of serum T[4], thyroid stimulating hormone [TSH] and TSH receptor blocking antibodies [TRBAb] in venous samples. In 43 primarily diagnosed as cases of CH, treatment was discontinued at age 2-3 years for 4 weeks and T[4] and TSH were measured again. Permanent or transient CH was determined from the results of these tests and radiologic evaluation. The incidence of congenital hypothyroidism was found to be 1:1465 with a female to male ratio of 1.19:1. The most common clinical findings were prolonged jaundice [73%], large anterior fontanel [56%] and wide posterior fontanel [55%]. In 43 patients with CH, prevalence of permanent and transient form of the disorder was 53.6% and 46.4% respectively. Permanent CH was associated with higher initial TSH level than transient hypothyroidism [P<0.001]. The most common etiology of permanent CH was dyshormonogenesis [57%]. TRBAb was found in 6.8% of the total 43 cases. Congenital hypothyroidism in Iran may have different etiologies. Due to higher rate of transient CH than other similar researches, it is reasonable to follow these patients for a longer period to rule out the possibility of permanent hypothyroidism