association between knowledge creation and organizational innovation in Tehran university of medical sciences

This study was designed to investigate the association between knowledge creation and organizational innovation among the staff of Tehran University of Medical Sciences [TUMS]. In this descriptive correlational study, 132 individuals from TUMS employees were randomly selected based on Cochran's formula. The questionnaires of knowledge creation management and organizational innovation were created by the researchers and their reliability was measured by Cronbach's alpha coefficient for the 0.87 and 0.85. After data collection, the statistical analysis methods, such as descriptive and inferential statistics, mean and standard deviation were performed. Pearson and Friedman test were carried out to obtain their correlation status. The relationship between knowledge creation components and the components of organizational innovation [product innovation, process innovation and administrative innovation] using Pearson analysis was significant [P < .001]. Knowledge creation and organizational innovation is at an encouraging level in TUMS.

Electrochemical synthesis of novel 1, 3-indandione derivatives and evaluation of their antiplatelet aggregation activities

Electrochemical oxidation of some selected catechol derivatives, using cyclic voltammetry, in the presence of different 2-aryl-1, 3-indandiones as nucleophiles, resulted in electrochemical synthesis of new 1, 3- indandione derivatives in an undivided cell in good yield and purity. A Michael addition mechanism was proposed for the formation of the analogs based on the reaction conditions which were provided in electrochemical cell. The in-vitro antiplatelet and anticoagulant activity of these compounds was evaluated, using arachidonic acid [AA] and adenosine diphosphate [ADP] as the platelet aggregation inducers. The results show that the incorporation of catechol ring in 1, 3-indandione nucleus leads to the emergence of antiplatelet aggregation activity in these compounds. The compounds may exert their antiaggregation activity by interfering with the arachidonic acid pathway

Synthesis and cytotoxic evaluation of novel 3-substituted derivatives of 2-indolinone

The assessment of the degree or rate of cellular proliferation and cell viability is critical for the assessment of the effects of drugs on both normal and malignant cell populations. In the present study, a few novel 3-substituted derivatives of 2-indolinones were synthesized by condensation of substituted oxindole or isatin derivatives with appropriate aldehydes or primary aromatic amines respectively. The synthesized compounds were screened for their cytotoxicity against HT-29 [human colon adenocarcinoma cell line] and MCF-7 [human breast adenocarcinoma cell line] cells using short term cytotoxicity MTT assay protocol. A few derivatives with IC[50] < 10 microM were identified among them. The compound bearing 5-bromo substitution was the most potent derivative. Global physicochemical properties for compounds IVa-e and Va-h were calculated and the two most active compounds [IVa and IVb] showed similar Clog P-values